Registration Dossier
Registration Dossier
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EC number: 814-217-0 | CAS number: 353258-35-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: shake flask method
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Results and discussion
Water solubilityopen allclose all
- Key result
- Water solubility:
- 0.16 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- Remarks on result:
- other: double distilled water
- Key result
- Water solubility:
- 0.25 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 4
- Remarks on result:
- other: buffer solutions of pH 4.0
- Key result
- Water solubility:
- 1.45 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 9
- Remarks on result:
- other: buffer solutions of pH 9.0
Applicant's summary and conclusion
- Conclusions:
- Water solubility in double distilled water (20 ± 0.5°C): 0.16 ± 0.01 g/L
Water solubility (pH 4.0, 20 ± 0.5°C): 0.25 ± 0.02 g/L
Water solubility (pH 9.0, 20 ± 0.5°C): 1.45 ± 0.02 g/L - Executive summary:
The water solubility was determined using the shake flask method described in the Guidelines – OECD 105 and OPPTS 830.7840. The solubility of the test substance was studied in double distilled water, buffer solutions of pH 4 and 9 at 20 ± 0.5°C. The samples were analysed by high-performance liquid chromatography.
Mean water solubility of the test substance in double distilled water, buffer solutions of pH 4.0 and 9.0 was 0.16 ± 0.01, 0.25 ± 0.02 and 1.45 ± 0.02 g/L, respectively at 20 ± 0.5°C.
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