Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-933-3
CAS number: 112-07-2
All mice in the 1100.00 mg/kg bw dose group died, whereas all mice in
the 550 mg/kg bw dose group survived. The frequency of micronucleated
PCEs per 1000 cells in the vehicle control group was 2.5
0.2 and the range of means in the dose groups was from 2.3 0.3
at 34.38 mg/kg bw to 3.8 0.8
at 137.50 mg/kg bw. The latter result swas statistically significantly
different in a pairwise comparison with the control. The trend test was
not significant (P= 0.236) and the paired comparison test gave P
= 0.05, whereas P
0.008 was required for statistical significance.
* statistically significantly different from vehicle control.
A reliable in vivo micronucleus induction test was performed with male
mice at dose levels up to those causing lethality. The mice were
injected intraperitoneally three times at 24 h intervals with 2
-butoxyethanol dissolved in phosphate-buffered saline at dose levels of
up to 1100 mg/kg bw per day. All of the animals in the top dose group
died; all other animals survived. A statistically significant increase
in the number of micronucleated polychromatic erythrocytes was seen in
one of the five remaining dose groups in a pairwise comparison with the
control (138mg/kg) but as this was not seen in any other dose group sna
dhte analysis for trend was not significant this leads to a conclusion
of a negative response. This result can be extrapolated to the acetate
ester of this substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again