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EC number: 203-933-3
CAS number: 112-07-2
All mice in the 1100.00 mg/kg bw dose group died, whereas all mice in
the 550 mg/kg bw dose group survived. The frequency of micronucleated
PCEs per 1000 cells in the vehicle control group was 2.5
0.2 and the range of means in the dose groups was from 2.3 0.3
at 34.38 mg/kg bw to 3.8 0.8
at 137.50 mg/kg bw. The latter result swas statistically significantly
different in a pairwise comparison with the control. The trend test was
not significant (P= 0.236) and the paired comparison test gave P
= 0.05, whereas P
0.008 was required for statistical significance.
* statistically significantly different from vehicle control.
A reliable in vivo micronucleus induction test was performed with male
mice at dose levels up to those causing lethality. The mice were
injected intraperitoneally three times at 24 h intervals with 2
-butoxyethanol dissolved in phosphate-buffered saline at dose levels of
up to 1100 mg/kg bw per day. All of the animals in the top dose group
died; all other animals survived. A statistically significant increase
in the number of micronucleated polychromatic erythrocytes was seen in
one of the five remaining dose groups in a pairwise comparison with the
control (138mg/kg) but as this was not seen in any other dose group sna
dhte analysis for trend was not significant this leads to a conclusion
of a negative response. This result can be extrapolated to the acetate
ester of this substance.
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