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EC number: 203-933-3
CAS number: 112-07-2
The continuous breeding first generation study showed that treatment
significantly affected fertility at the mid and high dose levels and
marginally affected pup weight at the lowest level. The cross-breeding
results suggest that the fertility effects were only due to effects on
the female mice. In the cross-over study there were no effecting on
mating index (number with copulatory plugs/number co-habited), however
for females that co-habited with control males the fertility index
(number fertile/number with copulatory plugs) ws significantly reduced
compared to the controls and other cross-over group. Similarly, the
number of live pups/litter of the 1% treated females/control males fell.
These effects may have been an indirect consequence of the severe
general systemic toxicity rather than a direct effect of 2-butoxyethanol
on the reproductive organs.
continuous breeding study carried out to an NTP protocol, mice were
exposed for a period of 14 weeks to the oral drinking water routes at
doses from 720 to 2050mg/kg. Significant adverse reproductive effects
were observed in the females at very high dose levels (1340 mg/kg and
above) which also caused severe general toxicity, including death. Under
the conditions of the study, the NOAEL for reproductive toxicity of
2-butoxyethanol (fertility) can be set as 720 mg/kg/day. For
developmental toxicity, no NOAEL can be derived. A conservative LOAEL of
720 mg/kg/day can be taken as only a very slight decrease in pup weight
was observed at this dose.
lowest dose studied, the only adverse finding was a marginal
statistically significant reduction in pup weight. However, since this
reduction was only 3% compared to controls and was not repeated in the
F1 generation, it was not considered a significant adverse finding.
No NOAEL or
LOAEL can be determined for systemic parental toxicity because this kind
of study is not designed to assess systemic toxicity although it is of
note that there were effects (reduced fluid consumption) even at the
lowest dosage of 720 mg/kg/day. On a molar basis, these results would
need to be increased by a factor of 1.36 to covert to a NOAEL/LOAEL for
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