2-butoxyethyl acetate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Acceptable study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Objective of study:

metabolism

toxicokinetics

Principles of method if other than guideline:

Using an in-vitro test system (rat plasma), metabolism of glykol monobutyl ether acetate to ethylene glykol monomethyl ether was investigated in relation to an internal standard with gas chromatography (GC).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-butoxyethyl acetate

EC Number:

203-933-3

EC Name:

2-butoxyethyl acetate

Cas Number:

112-07-2

Molecular formula:

C8H16O3

IUPAC Name:

2-butoxyethyl acetate

Details on test material:

- Name of test material (as cited in study report): Butylglykoletheracetat
- Physical state: liquid
- Analytical purity: > 99 %

Radiolabelling:

no

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Administration / exposure

Route of administration:

other: in vitro, test compound was added to 500 µL plasma of rats

Vehicle:

water

Duration and frequency of treatment / exposure:

2 to 20 min

Doses / concentrations

Remarks:

Doses / Concentrations:
0.2 µL/500 µL plasma (0.4 ‰ v/v)

Positive control reference chemical:

internal standard: ethylene glycol monomethylether

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters

Test no.:

#1

Toxicokinetic parameters:

half-life 1st: 0.96 minutes

Metabolite characterisation studies

Metabolites identified:

not measured

Any other information on results incl. tables

Butoxy ethyl acetate is deacetylated very rapidly to butoxyethanol in rat serum. Half-life of the substance in the rat plasma determined by gas chromatography was 0.96 minutes.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no bioaccumulation potential based on study results
It can be concluded that butoxyethyl acetate entering the blood is broken down very rapidly to the parent glycol ether 2-butoxyethanol (~95% within 4-5 minutes). The systemic toxicity of 2-butoxyethyl acetate will therefore be the same as the parent glycol ether 2-butoxyethanol.

Executive summary:

An in vitro study examined the rate of hydrolysis of 2 -butoxyethyl acetate (2BA) in rat blood plasma. 2BA was deacetylated very rapidly to butoxyethanol in rat serum with a half life of 0.96 minutes. It can be concluded that butoxyethyl acetate entering the blood is broken down very rapidly to the parent glycol ether 2-butoxyethanol (~95% within 4-5 minutes). The systemic toxicity of 2-butoxyethyl acetate will therefore be the same as the parent glycol ether 2-butoxyethanol.