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Diss Factsheets
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EC number: 203-933-3 | CAS number: 112-07-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Three studies are available in three different fish species. Of these, two tested for the required period of 96hrs and both gave consistent results. The key study indicated an LC50 somewhere between 20mg/l (the LC100) and 40mg/l (the LC0). The estimated LC50 of 28mg/l is used as the key value. There are no chronic fish studies available but these are not required to establish a suitable PNEC.
A number of studies in invertebrates have been carried out using multiple species, both fresh and salt water. These indicate that 2 -butoxyethyl acetate is somewhat toxic to invertebrates. A number of studies are available in the preferred species daphnia magna. One of these was not performed for the normally required 48hrs (only 24hr studies) however 3 studies were carried out for the requisite period. Of these studies, two of the study reports are available (Devillers and BASF) and the average of these two results is used as the value for the key parameter for fresh water. One reliable chronic study is available in invertebrates. There is no chronic data available in saltwater species.
There is limited data available on the toxicity of 2 -butoxyethyl acetate to algae, but sufficient to meet the requirements of the end point. Two experimentally derived results are available, both showing relatively low toxicity to the species. The study used to derive the key parameter shows the lower of the two results and is to a modern protocol. It is deemed reliable, although the available publication is not particularly detailed. Overall, the data is sufficient to judge with confidence that the substance is of low toxicity to algae and is sufficient to provide a NOEC for use in deriving the PNEC for the aquatic compartment.
Three valid studies in micro-organisms are available. One of these was effectively a limit test and showed no significant effects on sewage derived micro-organisms up to the top dose tested of 500mg/l. The second test showed an EC20 value of around 900 -1000mg/l. The third test was a toxicity test using the bacteria Pseudomonas putida. Both EC10 and EC50 values were determined. The results from this were consistent with the sewage sludge results and since they are absolute values for the effects are therefore used to derive the key parameters. Clearly the substance has relatively low toxicity to bacteria.
Two long term test results from two species representing two trophic levels (primary consumers and primary producers) will be used to derive the PNECaqua for this substance.
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