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EC number: 203-933-3
CAS number: 112-07-2
There is no mutagenicity data available on the substance 2 -butoxyethyl
acetate. In view of the rapid hydrolysis of this substance to the parent
glycol ether 2 -butoxyethanol under physiological conditions, the
mutagenic potential of 2 -butoxyethyl acetate in vivo is likely to be
similar to that of 2 -butoxyethanol. A summary of the key data for the
latter, that are presented as summaries in this chapter, is presented
Reliable studies indicate that 2 -butoxyethanol (2BE) is not mutagenic
In a reliable in vitro mammalian cell gene mutation assay, chinese
hamster ovary cells (CHO-K1-BH4-D1) were exposed to 2 -butoxyethanol up
to concentrations of 1% (v/v), with or without an S-9 metabolic
activating system from Arochlor 1254 induced rat liver. Doses were
selected based on low cytotoxicity to CHO cells in a preliminary study.
No treatment-related effects were seen, either in the presence or
absence of a metabolic activating system.
No evidence for chromosomal aberration induction was found in a
mammalian cell culture study with 2 -butoxyethanol.
The balance of evidence suggests that mutagenicity is not an important
property of 2 -butoxyethanol
There is no evidence for micronucleus induction in bone marrow cells or
interaction with DNA in several organs of rats. The possibility of
non-disjunction occurring and not being detected in these assays appears
to be remote, because the main metabolite of 2 -butoxyethanol (2BE),
butoxyacetic acid (BAA), produced no evidence of aneugenicity in vitro.
BAA is rapidly formed in vivo and is by far the most prevalent
blood metabolite of 2BE, so exposure of possible target cells to either
2BE or the intermediate transient metabolite butoxyacetaldehyde at high
concentrations is brief.
The clear balance of evidence suggests that 2 -butoxyethanol does not
pose a significant mutagenic potential in vivo.
Short description of key information:
Key data for read across substance:
- negative (with and without metabolic activation.) TA97, TA98, TA100, TA1535, TA1537, WP2uvrA.
- negative (with and without metabolic activation) CHO cells
Gene mutation, mammalian cells
- negative (without metabolic activation) AS52 cells grt locus. (BAL tested separately and negative)
Sister chromatid exchange
Negative (Micronucleus test, F344 rat)
Negative (Micronucleus test, B6C3F1 mouse)
Endpoint Conclusion: No adverse effect observed (negative)
There is no clear evidence of mutagenicity for the in vivo hydrolysis
product of 2 -butoxyethyl acetate, namely 2 -butoxyethanol. In
particular, the in vivo data is clearly negative from a number of
studies. 2 -butoxyethyl acetate is therefore unlikely to present a
biologically relevant genotoxic potential and therefore classification
is not warranted.
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