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EC number: 203-933-3
CAS number: 112-07-2
in vivo: 5 studies reporting 'not irritating'
in vitro: 6 studies reporting results consistent with 'low irritancy potential'
in vivo: 2 studies reporting 'not irritating'
in vitro: 2 studies reporting results consistent with 'low irritancy potential'. (One of these is not available for review.)
A number of skin irritation studies are available for 2 -butoxyethyl
acetate (2BA). Most of them are poorly reported and do not follow the
experimental conditions recommended in the European guidelines but they
all consistently indicate that 2BA is not irritant or slightly irritant.
Three studies were reported to be carried out in accordance with the
guidelines, although individual results are not presented for two and
one only reports full data for a single animal. All of these studies
reported little or no irritancy. There are also a number of in vitro
studies reported where 2BA was used alongside a number of other
substances in projects to develop alternative in vitro tests to avoid
the use of animal studies. These also consistently report results
consistent with a low potential for skin irritancy. A weight of evidence
approach is used to conclude a low potential for skin irritancy.
Three in vivo animal studies are available. All have some shortcomings
but all consistently show that 2BA is only a slight and transient eye
irritant substance. 2BA has also been tested in two in vitro alternative
tests and these two both show a low potential for eye irritancy.
Overall, the weight of evidence, alongside the general observation that
esters of simple alcohols are not generally eye irritants, leads to the
conclusion that this substance has a low potential for eye irritation.
No data available. No indication that respiratory irritation is likely
to be a property of this substance.
Skin irritancy: The authoris of both studies carried out to
current guidelines concluded that the substance is not a skin irritant
according to the European classification criteria. The data presented
along with other available information support this conclusion. No
classification is therefore warranted for skin irritation.
weight of evidence available indicates a low potential for irritancy to
the eye. There is no data that indicates levels of irritation that
approach that required to trigger classification as an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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