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EC number: 203-933-3
CAS number: 112-07-2
Absorbed dose over time:
HPLC analysis of urine showed the following metabolites in the
cumulative percentages of applied dose shown:
ethylene glycol (0.6%)
butoxyacetic acid (7.9%)
Glucoronide and conjugate (2.6%)
sulphate conjugate (0.7%)
The microautoradiographs showed a low density of silver grains on or
slightly above the stratum corneum and on hair shafts with background
levels in the remaining layers of skin. There was no evidence of
localization within skin appendages.
In a study in rats, topical application of radiolabelled 2-butoxyethanol
resulted in 28% of the applied dose being absorbed over a 24 hour period
(24% in 7 hours). Nearly 90% of the absorbed material was excreted
within this 24 hour period and only 1.4% remained in the carcass. The
dominant metabolite was butoxyacetic acid eliminated in the urine.
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