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EC number: 203-933-3
CAS number: 112-07-2
In a range finder study, rats were exposed by inhalation to
butoxyethanol at doses up to 500ppm for a period of 14 weeks. The study
approximated to guideline but parameters known to be insensitive to this
substance were not examined. Substantial toxicity was noted at the
higher doses but the predominant effects at lower doses were adverse
changes to the haematology, particularly haematocrit, hemoglobin,
erythrocytes reductions. No NOAEC was found for female rats; the LOAEL
was 31 ppm based on haematological effects seen at all doses tested. It
should be noted that although the effects were dose related and
statistically significant, at 31ppm the reduction in these parameters
was only around 5%. A NOAEL of 62.5 ppm was found for male rats, based
on haematotoxic effects seen at 125 ppm.
NOAEL (rats, 14 weeks, inhalation): males 62.5ppm, females <31ppm.
Similar values would apply for butoxyethyl acetate.
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