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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Daphnia magna. 48hr EC50 =67.5mg/l (protocol: ISO6341)

Rotifer (Brachionus sp.) 48hr EC50 (reproduction) = 303mg/l (protocol: AFNOR)

Oyster (Crassostrea sp.) 24hr NOEC (developmental toxicity) >100mg/l.  EC100<1000mg/l

Daphnia magna. 48hr EC50 = 37mg/l (DIN protocol)

Daphnia magna 48hr EC50/LC50 = 143mg/l, 180mg/l

Mysid.  48hr EC50 =70,609mg/l (protocol: QSAR)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
37 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
100 mg/L

Additional information

A number of studies have been carried out using multiple species, both fresh and salt water. These indicate that 2 -butoxyethyl acetate is somewhat toxic to invertebrates. A number of studies are available in the preferred species daphnia magna. One of these was not performed for the normally required 48hrs (only 24hr studies), however 3 studies were for the requisite period. Of these studies, two of the study reports are available (Devillers and BASF) and the lower of these is used as the value for the key parameter for fresh water. In a 48 hour acute toxicity study, rotifers showed a reduction in reproduction rate from concentrations of ~7mg/l upwards but an EC50 of 303mg/l. However, the results showed a very shallow dose response curve and wide confidence intervals and should to be used with caution. In the study in oyster larvae, there was no evidence of developmental effects after 24hrs exposure to concentrations up to 100mg/l