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EC number: 202-486-1 | CAS number: 96-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: - review article on 19 different substances lacking individual animal data and giving only limited information on methodological details + limited information from the SIDS report study summary - original study report not available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Testing of selected workplace chemicals for teratogenic potential.
- Author:
- Hardin BD, Bond GP, Sikov MR, Andrew FD, Beliles RP, Niemeier RW.
- Year:
- 1 981
- Bibliographic source:
- Scand J Work Environ Health. 1981;7 Suppl 4:66-75
- Reference Type:
- secondary source
- Title:
- SIDS INITIAL ASSESSMENT REPORT For SIAM 18 - 1,2,3-Trichloropropane
- Author:
- OECD
- Bibliographic source:
- Published OECD SIDS initial assessments of HPV chemicals: http://www.oecd.org/document/63/0,3343,en_2649_34379_1897983_1_1_1_1,00.html
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - generally equivalent to OECD TG 414 but only 1 concentration tested
- pregnant Sprague Dawley rats were treated with a previously determined MTD of 80 mg/Kg bw 3-chloropropene from gestation day 1 to 15 via i.p. injection. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,3-trichloropropane
- EC Number:
- 202-486-1
- EC Name:
- 1,2,3-trichloropropane
- Cas Number:
- 96-18-4
- Molecular formula:
- C3H5Cl3
- IUPAC Name:
- 1,2,3-trichloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 250 - 300 g
- no further details reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: no data
VEHICLE
- Justification for use and choice of vehicle (if other than water): no justification given, but corn oil is the standard vehicle for volatile organic solvents
- no further details given - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- not applicable
- Details on mating procedure:
- - Impregnation procedure: cohoused
- If cohoused:
- M/F ratio per cage: 1/1
- Length of cohabitation: not detailed
- Proof of pregnancy: sperm in vaginal smear day 1 of pregnancy - Duration of treatment / exposure:
- gd 1 - 15
- Frequency of treatment:
- daily
- Duration of test:
- until gd 21
- No. of animals per sex per dose:
- 10 - 15
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: MTD based on a dose finding study with non-pregnant rats (MTD: dose without mortality, no marked signs of toxicity and less than 10 % reduction of bw gain within 2 weeks after last treatment
- Rationale for animal assignment (if not random): not reported
Examinations
- Maternal examinations:
- - sacrifice on gd 21 of gestation and gross necroscopy of dams and weighing and preservation (10 % formalin) of the brain, heart, lungs, liver, spleen, kidneys, adrenals, and ovaries for histopathological examination.
- Ovaries and uterine content:
- - examination of uterine content
- Fetal examinations:
- - weighing of fetuses, measurement of crownrump length, sex determination and examination for externally visible malformations.
- internal examination of 50 - 66 % of each litter (preserved in Bouin's fluid)
- preservation of the rest of the litter in ethanol for clearing and skeletal staining with alizarin red. - Statistics:
- not reported
- Indices:
- not reported
- Historical control data:
- not reported
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
maternal effects only reported in a summary:
at least organ weights of 2 organs affected
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Basis for effect level:
- other: maternal toxicity
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
- Dose descriptor:
- LOAEL
- Effect level:
- 37 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- 37 mg/kg bw/day
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- 1,2,3-trichloropropane was tested for developmental toxicity in a study generally compliant to OECD 414. Pregnant Sprague Dawley rats were treated with a previously determined MTD of 37 mg/Kg bw from gestation day 1 to 15 via i.p. injection.
Maternal toxicity was found at the only tested dose but no signs of fetal toxicity or teratogenicity. Therefore a NOAEL of 37 mg/Kg bw can be derived for developmental toxicity, though the reliability of the study is limited due to the design of the study a screening test. - Executive summary:
In the present study (Hardin 1981) 1,2,3-trichloropropane was tested for developmental toxicity in a general compliance to OECD 414. Pregnant Sprague Dawley rats were treated with a previously determined MTD of 37 mg/Kg bw from gestation day 1 to 15 via i.p. injection. At gestation day 21 they were sacrificed and a full teratology examination was performed.
Maternal toxicity was found at the only tested dose but no signs of fetal toxicity or teratogenicity. Therefore a NOAEL of 37 mg/Kg bw can be derived for developmental toxicity, though the reliability of the study is limited due to the design of the study a screening test (only one dose was tested and as individual animal data and methodological details are not reported).
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