Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-486-1
CAS number: 96-18-4
In the present study (Hardin 1981) 1,2,3-trichloropropane was tested for
developmental toxicity in a general compliance to OECD 414. Pregnant
Sprague Dawley rats were treated with a previously determined MTD of 37
mg/Kg bw from gestation day 1 to 15 via i.p. injection. At gestation day
21 they were sacrificed and a full teratology examination was performed.
Maternal toxicity was found at the only tested dose but no signs of
fetal toxicity or teratogenicity. Therefore a NOAEL of 37 mg/Kg bw can
be derived for developmental toxicity, though the reliability of the
study is limited due to the design of the study a screening test (only
one dose was tested and as individual animal data and methodological
details are not reported).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again