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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Hardin 1981) 1,2,3-trichloropropane was tested for
developmental toxicity in a general compliance to OECD 414. Pregnant
Sprague Dawley rats were treated with a previously determined MTD of 37
mg/Kg bw from gestation day 1 to 15 via i.p. injection. At gestation day
21 they were sacrificed and a full teratology examination was performed.
Maternal toxicity was found at the only tested dose but no signs of
fetal toxicity or teratogenicity. Therefore a NOAEL of 37 mg/Kg bw can
be derived for developmental toxicity, though the reliability of the
study is limited due to the design of the study a screening test (only
one dose was tested and as individual animal data and methodological
details are not reported).
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