Registration Dossier
Registration Dossier
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EC number: 202-486-1 | CAS number: 96-18-4
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
With regard to persistency 1,2,3-Trichloropropane (TCP) was found not readily biodegradable (MITI 1992). On the other hand the analysis of the parent compound indicated clearly its transformation (MITI 1992). TCP was reported to biodegrade in aerobic soil (Anderson et al 1991) with a half life of 2.7 days and in anaerobic sediment (Peijnenburg et al 1998) with a half life of 7 days. With regard to degradation products of TCP, primary degradation to 2,3-dichloro-1-propanol (CAS 616-23-9) in anaerobic conditions byAgrobacterium radiobacteris reported (Bosma et al (1999). Bosma & Janssen (1998) found TCP oxidized to 2,3-dichloropropionaldehyde (CAS 10140-89-3) and 1,3 dichloroacetone (534-07-6 ) byMethylosinus trichosporium. Finally reductive dehalogenation of TCP is reported from Yan et al (2009). 3-chloro-1-propene (107-05-1), which is chemically unstable, was produced from TCP by strictly anaerobic bacterial strains isolated from contaminated groundwater.
The atmospheric dissipation half life of TCP is estimated by QSAR to be 30.5 days due to hydroxylation (indirect Photolysis, Martinko 2002). However the compound can not be finally assessed on the basis of this information primary degradation is evidenced.
The toxicokinetic studies in rats from Mahmood et al (1991) and Volp et al (1984) proved complete mineralisation of TCP to carbon dioxide (CAS 124-38-9) which was found in both studies, while the14C-label position was at carbon 2 and 1 or 3 respectively. Accordingly the complete degradation of TCP in biota is considered. The in vitro investigation of Weber & Sipes (1992) suggest Bischloromethyl ketone (CAS 534-07-6) as intermediate transformation product.
In conclusion TCP may be persistent in water (> 60 days), but gets primarily degraded in the atmosphere, in aerobic soils and in anaerobic sediments as experimentally proven. Bacterial transformation in aerobic soils is likely.
1,2,3 -Trichloropropane is not bioaccumulative having a BCF of about 5 to 13 L/kg (MITI 2002), and the log Pow of 2.63 poses no concern (Lide 2008). In conclusion, the compound is assessed not B and not vB.
With regard to toxicity it is to consider that 1,2,3 -Trichloropropane is classified carcinogenic category 2 on the basis of Irwin et al (1995). In conclusion, the compound is assessed T.
The available data on TCP show that the properties of the substance do not meet the specific criteria detailed in Annex XIII or do not allow a direct comparison with all the criteria in Annex XIII but nevertheless indicate that the substance would not have these properties and the substance is not considered a PBT/vPvB.
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