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EC number: 202-486-1
CAS number: 96-18-4
With regard to persistency 1,2,3-Trichloropropane (TCP) was found
not readily biodegradable (MITI 1992). On the other hand the analysis of
the parent compound indicated clearly its transformation (MITI 1992).
TCP was reported to biodegrade in aerobic soil (Anderson et al 1991)
with a half life of 2.7 days and in anaerobic sediment (Peijnenburg et
al 1998) with a half life of 7 days. With regard to degradation products
of TCP, primary degradation to 2,3-dichloro-1-propanol (CAS 616-23-9) in
anaerobic conditions byAgrobacterium radiobacteris reported
(Bosma et al (1999). Bosma & Janssen (1998) found TCP oxidized to
2,3-dichloropropionaldehyde (CAS 10140-89-3) and 1,3 dichloroacetone
(534-07-6 ) byMethylosinus trichosporium. Finally reductive
dehalogenation of TCP is reported from Yan et al (2009).
3-chloro-1-propene (107-05-1), which is chemically unstable, was
produced from TCP by strictly anaerobic bacterial strains isolated from
The atmospheric dissipation half life of TCP is estimated by QSAR
to be 30.5 days due to hydroxylation (indirect Photolysis, Martinko
2002). However the compound can not be finally assessed on the basis of
this information primary degradation is evidenced.
The toxicokinetic studies in rats from Mahmood et al (1991) and
Volp et al (1984) proved complete mineralisation of TCP to carbon
dioxide (CAS 124-38-9) which was found in both studies, while the14C-label
position was at carbon 2 and 1 or 3 respectively. Accordingly the
complete degradation of TCP in biota is considered. The in vitro
investigation of Weber & Sipes (1992) suggest Bischloromethyl ketone
(CAS 534-07-6) as intermediate transformation product.
In conclusion TCP may be persistent in water (> 60 days), but gets
primarily degraded in the atmosphere, in aerobic soils and in anaerobic
sediments as experimentally proven. Bacterial transformation in aerobic
soils is likely.
1,2,3 -Trichloropropane is not bioaccumulative having a BCF of
about 5 to 13 L/kg (MITI 2002), and the log Pow of 2.63 poses no concern
(Lide 2008). In conclusion, the compound is assessed not B and not vB.
With regard to toxicity it is to consider that 1,2,3
-Trichloropropane is classified carcinogenic category 2 on the basis of
Irwin et al (1995). In conclusion, the compound is assessed T.
The available data on TCP show that the properties of the substance do
not meet the specific criteria detailed in Annex XIII or do not allow a
direct comparison with all the criteria in Annex XIII but nevertheless
indicate that the substance would not have these properties and the
substance is not considered a PBT/vPvB.
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