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EC number: 202-486-1 | CAS number: 96-18-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- other: handbook data
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A reliability code of 2 is assigned to data from recognized reference handbooks / data collections.
- Reason / purpose for cross-reference:
- reference to other study
- Guideline:
- other: no data
- Principles of method if other than guideline:
- Handbook data, no details on methodology given.
- GLP compliance:
- not specified
- Type of method:
- other: handbook data
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Type:
- log Pow
- Partition coefficient:
- 2.63
- Temp.:
- 25 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- 1,2,3-Trichloropropane has a log Pow of 2.63 at 25 °C.
- Executive summary:
According to the 89th ed. of the CRC Handbook, 1,2,3-Trichloropropane has a a log Pow of 2.63 at 25 °C.
- Endpoint:
- partition coefficient
- Type of information:
- other: data from handbook
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The National Institute of Technology and Evaluatuion (NITE) is referring to the CRC Handbook 84th ed. A reliability code of 2 is assigned to data from recognized reference handbooks / data collections.
- Guideline:
- other: no data
- Principles of method if other than guideline:
- Handbook data, no details on methodology given.
- GLP compliance:
- not specified
- Type of method:
- other: handbook data
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Type:
- log Pow
- Partition coefficient:
- 2.63
- Temp.:
- 25 °C
- pH:
- >= 0 - < 14
- Conclusions:
- 1,2,3-Trichloropropane has a log Pow of 2.63 at 25 °C.
- Executive summary:
According to the Chemical Risk Information Platform (CHRIP) of the National Institute of Technology and Evaluation (NITE, Japan), which is referring to the CRC Handbook, 1,2,3-Trichloropropane has a log Pow of 2.63 at 25 °C.
- Endpoint:
- partition coefficient
- Type of information:
- other: data from handbook
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A reliability code of 2 is assigned to data from recognized reference handbooks / collection of data.
- Guideline:
- other: no data
- Principles of method if other than guideline:
- Handbook data, no details on methodology given.
- GLP compliance:
- not specified
- Type of method:
- other: handbook data
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Type:
- log Pow
- Partition coefficient:
- 2.27
- Temp.:
- 20 °C
- pH:
- >= 0 - <= 14
- Details on results:
- Handbook data, no details given on pH during measurement.
- Conclusions:
- 1,2,3-Trichloropropane has a log Pow of 2.27 (measured).
- Executive summary:
The Ministry of International Trade and Industry, Japan, publishes in their compilation of "Data of Existing Chemicals" for 1,2,3-Trichloropropane a log Pow of 2.27 (measured). Original reference quoted in the 2004 SIDS dossier, not many details on the methodology available.
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study reported in the 2004 SIDS dossier. A reliability code of 2 is assigned to references that present scientifically-acceptable data.
- Guideline:
- other: no data
- Principles of method if other than guideline:
- calculation method
- GLP compliance:
- not specified
- Type of method:
- other: calculation method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: calculation method
- Type:
- log Pow
- Partition coefficient:
- 2.54
- Temp.:
- 20 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- 1,2,3-Trichloropropane has a log Pow of 2.54 (calculated).
- Executive summary:
Ruelle publishes in the year 2000 in the journal "Chemosphere" for 1,2,3-Trichloropropane a log Pow of 2.54 (calculated). Original reference quoted in the 2004 SIDS dossier, not many details on the methodology available.
Referenceopen allclose all
No details are given on pH during measurement.
No details are given on pH during measurement.
The log Pow is the result of a measurement. No details are given on pH and temperature during measurement, however it is assumed that the measurement was conducted in the usual temperature range of 20 -25 °C.
The log Pow is the result of a measurement. No details are given on pH and temperature during measurement, however it is assumed that the measurement was conducted in the usual temperature range of 20 -25 °C.
Description of key information
Based on a weight of evidence approach, 1,2,3-Trichloropropane has a a log Pow of 2.63 at 25 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.63
- at the temperature of:
- 25 °C
Additional information
Compilation of log Pow data of 1,2,3 -Trichloropropane:
| Data source | measured / calculated | temperature °C | log Pow |
| SIDS dossier 2004 (data taken from MITI 1992) | measured | 20 / 25 °C * | 2.23 |
| SIDS dossier 2004 (data taken from Ruelle 2000) | calculated | 20 / 25 °C * | 2.54 |
| NITE 2009 (data taken from CRC Handbook 84th ed.) | measured | 25 °C | 2.63 |
| Lide 2008 (CRC Handbook 89th ed.) | measured | 25 °C | 2.63 |
* No detailed information given on the temperature during measurement, however it is assumed that the temperature was in the usual range of 20 - 25 °C.
The log Pow values as shown above are consistent and indicate that the data set is robust. The preferred value is the log Pow as given by Lide 2008 (CRC Handbook 89th. ed.) and by NITE 2009, which is referring to the 84th. ed. of the CRC Handbook. These are also the two data sources which reported unambiguously clear the temperature during measurement. The original reference, as quoted in the CRS Handbook, is: Mackay D., 1992, Illustrated Handbook of Pysical-Chemical Properties and environmental fate of Organic Substances, Lewis Publishers / CRC Press, Boca Raton, FL, .
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