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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Shell Development Company, 1980) male and female
New Zealand White rabbits were treated once with undiluted 1,2,3
-trichloropropane dermaly under occlusive conditions for 24 h and
analysed for mortality, body weight development and clinical signs
following generally the OECD TG 403 in compliance with GLP.
The following threshold values were determined:
LD50 (dermal, rabbit, male) = 390 mg/Kg bw
LD50 (dermal, rabbit, female) = 765 mg/Kg bw
LD50 (dermal, rabbit, combined) = 523 mg/Kg bw
Based on this results 1,2,3 -trichloropropane is classified as Category
III (Toxic in contact with skin (dermal)) according to CLP (REGULATION
(EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as
implementation of UN-GHS in the EU.
Six male and 6 female New Zealand White rabbits were divided equally
into 7 dosage groups (except the lowest dose which had no females; 0.18,
0.32, 0.56, 0.78, 1.00, 1.80, and 3.20 mL/Kg bw (equivalent to: 253,
450, 788, 1097, 1406, 2530 and 4500 mg/Kg bw)). Their backs were shaved
and one half of the test animals were further prepared by abrading their
backs (deep enough to penetrate the stratum corneum but not to the
derma). The area was wrapped with gauze and occluded with clear
polyethylene film for 24 hours. After 24 hours the bandages were
removed, and the backs were gently wiped with a moist towel. Animals
were observed at 24 hours, and twice daily for 14 days. Body weights
measured at day 0, 7 and 14, or at the time of discovery of death. A
gross necropsy was performed on each animal.
The authors reported that severe dermal lesions were not present on any
animal at any time during the study. The most prevalent cageside in-life
observations included: activity decrease, ataxia and nasal discharge. As
dose increased the following additional signs were observed: few feces,
no urination, hematuria, swollen testes/urethra, iritis, cyanosis and
death. Gross necropsy observations included: discolored internal organs
(kidney, lungs, urinary bladder, liver, intestines); organs distended
with blood; mottled organs (kidney, liver); swollen testes; fluid in
abdominal cavity and pronounced serosal blood vessels on intestines.
Mortality was observed at all dose levels; all males died at 0.56 ml/kg
or higher, and all females at 1.0 ml/kg. The dermal LD50 in male rabbits
was 0.277 ml/kg (390 mg/kg); the dermal LD50 in females was 0.544 ml/kg
(765 mg/kg), slope of 2.52; and combined it was 0.372 ml/kg (523 mg/kg),
slope of 1.61
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