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EC number: 202-486-1
CAS number: 96-18-4
TCP may enter the hydrosphere due to its production, use, and
application. However, it can evaporate from the aqueous phase to some
extent, thus reducing the exposure concentration for aquatic species.
Such loss due to evaporation of TCP from the aqueous phase was
demonstrated in a recent study simulating a 48-h daphnid open vessel
test (Solvay 2001, Internal Memorandum).
The acute toxicity of TCP was tested using a variety of aquatic
species from the relevant trophic levels (producers and primary and
secondary consumers) represented by algae, invertebrates and fish. The
figures indicate that aquatic invertebrates are most susceptible to TCP
toxicity, followed by fish. TCP is not acute toxic to algae until the
regulatory cut-off limit of 100 mg/L.
Some of the aquatic toxicity studies are of limited value, because
actual concentrations of TCP were not measured and losses of the test
item due to volatilization were not taken into account over the tests’
duration (Kielhorn et al 2003). In this dossier such studies are rated
„Klimisch 3“ (K3) as they is the following restriction for the
interpretation of the study findings. The derived threshold
concentrations from these experiments mark the upper exposure level
rather than the actual exposure over the test duration. In conclusion
the dose descriptors from the K3 studies do on one hand not support to
raise the assigned overall effect level for an organism group over a
level from a more reliable experiment. On the other hand the results
give sufficient evidence to establish the value used for CSA, if they
represent the lowest one.
Use of closed test systems to reduce the losses of the test item
TCP and to assure exposure has recently been reported for two tests with
a microalga (Selenastrum capricornutum, de Groot 2001) and a
cladoceran (Daphnia magna, de Groot 2002). Based on measured
concentrations the EC50 values for
biomass and immobility were 50 and 20 mg/L, respectively.
For invertebrates one acute toxicty GLP and guideline study with
analytical measurements is available for Daphnia magna (De Groot
2002). This study reports EC50 of 20 mg/L. Another study with Ceriodaphnia
cf. dubia) is referenced by CICAD (Kielhorn 2003), and revealed a
noticable lower EC50 value of 4.1 mg/L.
Two studies are available with 21 day exposure. One follows the
OECD guideline 211 with Daphnia magna and found an EC10 for growth and
reproduction at 6 mg/L (arithmetic mean of measured concentration). The
NOEC of this study is 4.5 mgl/L. In another study only survival was
reported (EC50=20 mg/L). Given the observed higher sensitivity of Ceriodaphnia
cf. dubia as reported by Kielhorn 2003, the additional chronic study
for invertebrates is not used in the consideration of the assessment
A flow-through fish test with fathead minnow (Pimephales
promelas) revealed a LC50 96 h
value of 66.5 mg/L based on effective (measured) concentrations. For
fish, one study was done which included analytical measurements and
therefore a robust summary was prepared for this study. However, the
study was not done according to GLP and some details of the study were
lacking. For this reason two additional robust summaries were prepared
for two fish studies that were done in accordance with GLP regulations
and a recognized scientific method, although analytical measurements
were not conducted. (OECD SIDS 2004)
Aquatic invertebrates are the most sensitive organism group towards
1,2,3 Trichloropropane toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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