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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Shell Development Company, 1980d) male and female
New Zealand White rabbits got 0.1 mL undiluted 1,2,3 -trichloropropane
instilled into one eye and were analysed for eye irritation effects,
body weight development and clinical signs for 14 d following generally
the OECD TG 405 in compliance with GLP.
A maximum overall irritation score of 20/110 was reported for unwashed
eyes, and 16.3/110 for washed eyes. The test material was considered
moderately irritating by the authors of the study.
As no detailed individual data is available from the SIDS dossier in a
conservative approach 1,2,3 -trichloropropane is classified as Category
2 ( Causes serious eye irritationr) regarding eye irritation according
to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF
THE COUNCIL) as implementation of UN-GHS in the EU.
Nine rabbits, 3 males and 3 females in the unwashed group; 3 males in
the washed group were tested. Test material (0.1 ml) was placed into the
everted lower eye lid of 3 male and 3 female New Zealand White rabbits;
another 3 male rabbits received the same treatment but the eyes were
washed 30 seconds after instillation with tap water. Treated eyes of all
animals were evaluated for irritation at 1, 6, 24, 72 hours and at 7 and
14 days. Corneas were reexamined at the same time periods with 0.2%
sodium fluorescein. Animals were housed individually.
Superficial corneal ulcerations were detected in 4/6 unwashed eyes by 1
hour and in 5/6 by 6 hours; it was also observed in 2/3 washed eyes at
24 hours. The corneal ulceration reversed within 72 hours. Iritis was
observed in 5/6 unwashed (clear in 72 hours) and 1/3 washed (clear in 24
hours). Some conjunctival irritation remained in both groups for 7 days
(1/6 and 1/3, respectively). A maximum score of 20/110 was reported for
unwashed eyes, and 16.3/110 for washed eyes. Test material was
considered moderately irritating by the authors of the study..
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