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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Monsanto 1987) the acute respiratory toxicity of
1,2,3-trichloropropane was tested in compliance with OECD TG 403 in
Sprague-Dawley rats of both sexes at a limit dose of 4800 mg/m³
(exposure duration = 4 h). No fatalities occurred. Based on this result
1,2,3-trichloropropane should not be classified according to CLP
(REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE
COUNCIL) as implementation of UN-GHS in the EU.
Animals were probably whole body exposed in a New York University-style
stainless steel chamber (temp.: 26 °C; relative humidity: 35%; oxygen
level: 21%). Test item concentrations were analysed by gas
chromatography. Animals were subsequently observed for clinical signs
and body weight effects and sacrificed and necropsied 14 days after the
No fatalities occured at this limit dose, while during exposure
hypoactivity, lacrimation and slow labored breathing was reported. Post
exposure periocular wetness, clear nasal discharge, hypoactivity,
labored respiration, gasping, rattling sounds in lungs, red/brown
perinasal encrustation and ataxia were seen.At necropsy nevertheless no
adverse effects were reported.
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