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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Shell Development Company, 1980c) male and female
New Zealand White rabbits were treated once with 0.5 mL undiluted 1,2,3
-trichloropropane dermaly under occlusive conditions on abraded and
shaved skin for 24 h and analysed for skin reactions, body weight
development and clinical signs following generally the OECD TG 404 in
compliance with GLP.
An overall primary irritation index (PII) for abraded and shaved skin of
1.63 was observed.
Based on this result 1,2,3 -trichloropropane is not classified regarding
skin irritation according to CLP (REGULATION (EC) No 1272/2008 OF THE
EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in
Undiluted test material (0.5 ml) was applied to the shaved backs of test
animals; six rabbits were further prepared by abrading their backs (deep
enough to penetrate the stratum corneum but not to the derma). The area
was wrapped with gauze and occluded with clear polyethylene film for 24
hours. After 24 hours the bandages were removed and the test sites were
observed for erythema and edema. Their backs were then gently wiped with
a moist towel. All animals were again observed at 72 hours, and at day 7.
Erythema was present through 72 hours in abraded skin sites, and 24
hours in unabraded sites. Edema, which was observed initially and at 24
hours, was clear by 72 hours in both groups. The severity of the
response was greater in the abraded test sites. Individual scores ranged
from 1-2.5 in intact skin, and from 1-3 in abraded skin sites. Overall
PII was 1.63.
The authors state the substance as mildly irritating but according to
CLP no classification is needed based on this PII.
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