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EC number: 202-705-0
CAS number: 98-83-9
reproductive performance and postnatal survival of pups to weaning were
unaffected by styrene exposure.
Up to weaning,
F1 pup weights and developmental markers showed no effects of styrene
exposure, but subsequent direct exposure at 500 ppm reduced
weight gain. Associated
with this lower weight gain, delay to balanopreputial separation was
effects were more evident in F2 pups than in F1 pups: pre-weaning pup
weights were reduced in both 150 and 500 ppm groups and a significant
delay in mean age for incisor
eruption was seen in the 500 ppm group,
together with minor (statistically insignificant) delays to pinna
detachment, surface righting, hair appearance, eye opening, and
balanopreputial separation. Further
evidence of slight developmental delays for F2 animals of
the 500 ppm group were also reported: these included apparent changes in
locomotor activity development (postnatal
days 13-21), reduced swimming ability (postnatal day 24) and reduced
grip strength (postnatal days 45
and 60). These
F2 effects were considered to represent slight developmental delay
resulting from parental styrene exposure at 500 ppm.
Exposure of rats to styrene at up to 500 ppm (2.13 mg/l) for at least 70
days produced no evidence of adverse effect on reproductive performance,
teratogenicity or embryo-/foeto-toxicity. Some delay to postweaning
growth and postweaning developmental milestones (including certain
markers of neurological development) was reported, and this was more
evident in the F2 generation than in F1 animals. The authors concluded
NOAEC values of 500 ppm (2.13 mg/l) for F2 developmental neurotoxicity
and 50 ppm (0.21 mg/l) for F2 progeny growth.
Based on the justification document supplied in section 13 of this
dossier which supports the use of read-across from styrene to the
registered substance 2-phenylpropene, it is concluded that the observed
activity profile of styrene and NOAEC values determined in this study
can reasonably be considered applicable to the registered substance.
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