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EC number: 202-705-0
CAS number: 98-83-9
In this study
performed according to OECD Guideline 422, 1-methylethenylbenzene was
given to SD (Crj:CD) rats of both sexes at dose levels of 0, 40, 200 or
1000 mg/kg/day by oral administration for 43 days from 14 days prior to
mating to days after mating in males and for the periods including 14
days prior to mating and from gestation period, followed by delivery
until post-partum day 3 in females.
At 1000 mg/kg,
male rats showed a suppression of body weight gain, and a decrease in
food consumption, and one animal died due to ischuria with urinary
calculi. Female rats showed slight suppression of body weight gain in
the late gestation period. Histopathological examination demonstrated
increases of liver and kidney sizes, acidophilic change of hepatocytes
and increase of fatty droplets in the fascicular zone of the adrenals in
both sexes, increase of hyaline droplets and basophilic change in the
renal tubular epithelium, formation of urinary calculi and hyperplasia
of the mucosal epithelium in the urinary bladder in male rats, and
vacuolation and infiltration of lymphocytes in the renal tubular
epithelium and atrophy of the thymus in female rats. Blood chemical
examination in male rats showed increases in GPT, urea nitrogen and
potassium, and a decrease in triglyceride.
At 200 mg/kg,
similar histological changes were found in the liver and kidneys of both
sexes, and the thymus of female rats, and an increase in GPT was
observed in male rats. Haematological examination showed that the test
substance had no effects in males.
The LOAEL for
repeated dose toxicity was given with 200 mg/kg/day for both sexes. The
NOEL was 40 mg/kg bw/d. The NOAEL is expected to be >100 mg/kg bw/d.
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