Registration Dossier
Registration Dossier
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EC number: 202-705-0 | CAS number: 98-83-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity of alpha-methylstyrene to Daphnia magna was investigated in a study conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test; cited as OECD Guideline 202 (1984)). The calculation of inhibition of reproduction yielded a 21 d EC50=1.11 mg/L (95% c.i.: 1.03 -1.21 mg/L) and a 21 d NOEC=0.401 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.401 mg/L
Additional information
Reliable results obtained in a guideline study are available. The long-term toxicity of alpha-methylstyrene to Daphnia magna was investigated in a study conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test; cited as OECD Guideline 202 (1984)). 40 Daphnids were exposed to alpha-methylstyrene at nominal concentrations of 0 (control), solvent control, 0.08, 0.2, 0.5, 1.2, and 3.0 mg/L for 21 d under semi-static conditions. The test substance concentrations were monitored via HPLC/UV. The parental mortality (21 d LC50) was determined to be 1.56 mg/L (95% c.i.: 1.02 -2.40 mg/L) based on measured concentrations (TWA during 4 d). The calculation of inhibition of reproduction yielded a 21 d EC50=1.11 mg/L (95% c.i.: 1.03 -1.21 mg/L) and a 21 d NOEC=0.401 mg/L. At the concentrations tested (<=1.2 mg/L nominal) no effect on time of first brood was observed.
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