2-phenylpropene

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1956

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Older publication: Some experimental details are missing, but basic data given

Data source

Reference

Reference Type:

publication

Title:

Toxicological studies of certain alkylated benzenes and benzene. Experiments on laboratory animals

Author:

Wolf MA, Rowe VK, McCollister DD, Hollingsworth RL & Oyen F

Year:

1956

Bibliographic source:

AMA Arch Ind Health 14, 387 - 398

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

respiratory irritation

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Calculated amounts of the TS were introduced into the atmosphere of an enclosed, tightly sealed room. Utilising sensitive analytical procedures, the concentration within the room was determined. Then the subjects (no further information available) entered the room quickly and noted their reactions with respect to odour, eye irritation, and nasal irritation

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenylpropene

EC Number:

202-705-0

EC Name:

2-phenylpropene

Cas Number:

98-83-9

Molecular formula:

C9H10

IUPAC Name:

(prop-1-en-2-yl)benzene

Details on test material:

Name of test material (as cited in study report): alpha-Methyl styrene
Purity: 98.6 - 99.1 % (obtained by UV or IR analysis)
Boiling point: 165.4 degrees C
Specific gravity: 0.91 (at 20 degrees C)

Method

Type of population:

not specified

Subjects:

no further information available

Ethical approval:

not specified

Route of exposure:

inhalation

Reason of exposure:

intentional

Exposure assessment:

measured

Details on exposure:

Exposure from <= 10 to >= 600 ppm

Results and discussion

Clinical signs:

Response of the subjects:
< 10 ppm: odour not detectable
50 ppm: odour detectable, no mucous membrane irritation
100 ppm: strong tolerable odour
200 ppm: strong objectionable odour
>= 600 ppm: very strong odour, strong eye and nasal irritation

Results of examinations:

In this study with limited documentation, human volunteers were exposed to concentrations of <= 10 to >= 600 ppm. At the highest concentration of >= 600 ppm, the exposure caused strong eye and nasal irritation.

Applicant's summary and conclusion

Conclusions:

In this study with limited documentation, the exposure of human subjects to concentrations of >= 600 ppm caused strong eye and nasal irritation.

Executive summary:

In this study with limited documentation, human volunteers were exposed to concentrations of <= 10 to >= 600 ppm. At the highest concentration of >= 600 ppm, the exposure caused strong eye and nasal irritation.