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EC number: 202-705-0
CAS number: 98-83-9
In this study (design comparable to OECD Guideline 413),
groups of 10 male and 10 female rats were exposed by whole-body
inhalation to alpha-methylstyrene at concentrations of 0, 75, 150, 300,
600 or 1000 ppm for 6 hrs per day and 5 days per week for 14 weeks.
Additional clinical pathology groups of 10 male and 10 female rats were
exposed to the same concentrations for 23 days. All rats survived to the
end of the study, and mean body weights of all exposed groups were
similar to those of the chamber controls. Kidney weights were
significantly increased in 1000 ppm males and at >= 600 ppm females.
Statistically significant increases in liver weights occurred at >= 150
ppm males and at >= 600 ppm females. The incidences of renal hyaline
droplet accumulation were similar between exposed groups and chamber
control groups, but the severity of hyaline droplet accumulation in >=
600 ppm males was greater than in chamber controls. Consistent with the
hyaline droplet accumulation, an exposure related increase in
alpha2u-globulin was detected in the kidneys of males exposed to
alpha-methylstyrene. Morphologic changes were not detected in the liver.
The effects observed in male rats at concentrations of 300 and below are
not considered to be relevant for human health and a the relevant NOAEL
of 300 ppm has been derived.
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