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EC number: 202-705-0
CAS number: 98-83-9
oral LD50 (rat): ca. 4900 mg/kg bw (key study: Wolf et al., 1956)inhalation LC50 (6 hrs; rat): ca. 22850 mg/m3 (key study: Monsanto Co., 1972)dermal LD50 (NZW rabbit): ca. 14560 mg/kg bw (key study: Union Carbide Co., 1975)
For alpha-methylstyrene no studies performed according to recent
guidelines are available. However, the available studies, which have
some limitations concerning documentation or low number of animals in
study are indicating very low acute toxicity.
LD50 (rat): 4900 mg/kg bw (Wolf et al., 1956)
LD50 (rat): 2840 mg/kg bw (Monsanto Co., 1972)
LD50 (rat): ca. 5915 mg/kg bw (Union Carbide Co., 1975)
LD50 (rat): > 7940 to < 10000 mg/kg bw (Union Carbide Co., 1970)
Toxic signs were unspecific and included reduced appetite and
activity, weakness, ocular discharge, collapse and death and died
animals showed hyperaemia of lungs and liver and acute GI inflammation.
LD50 (rabbit): ca. 14560 mg/kg bw (Union Carbide Co., 1975)
MLD (rabbit): > 7940 mg/kg bw (Monsanto Co., 1970, 1972)
Toxic signs included reduced appetite and activity, weight loss,
skin erythema, and hiccup-like spasms.
LC50 (rat; 6 hrs): ca. 22850 mg/m3 (Monsanto Co., 1972)
rats with an exposure to ca. 41600 mg/m3 over 8 hrs: 2/6 animals
died during the exposure (Union Carbide Co., 1975)
Toxic signs included lethargy and collapse and the necropsy of
survivors showed slight congestion of lungs, while necropsy of died
animals showed haemorrhagic lungs, slight liver discoloration, and acute
Based on the available and reliable data there is no
classification of alpha-methylstyrene for acute toxicity (oral, dermal
and inhalation) based on EU regulation 1272/2008.
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