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EC number: 202-705-0
CAS number: 98-83-9
significant reductions in pituitary weight were seen
at 500 ppm in F2 male pups and at 150 and 500 ppm in
F2 females, only in F2 males at 500 ppm where
bodyweight-relative pituitary weight reduction was
also seen was a pituitary effect considered
attributable to styrene exposure. The
other cases, together with statistically significant
decreases in mean thymus and uterine weights in F2
females at 500 ppm, were judged likely to be
associated with growth retardation.
In this reliable study of styrene toxicity, no significant effect on
reproductive performance, or on morphology or function of reproductive
organs, was seen when rats were exposed to styrene (6h/dayover 2
generations) at concentrations up to 500 ppm (mean measured
concentration: equal to 2.1 mg/l) in this study. A NOAEC value of 50
ppm/0.21 mg/l was concluded for systemic toxicity to the F0 and F1
parental generations, together with a NOAEC value of 2.1 mg/l for
toxicity to reproduction. Based on the justification document supplied
in section 13 of this dossier which supports the use of read-across from
styrene to the registered substance 2-phenylpropene, it is concluded
that these NOAEC values and the observed absence of toxicity to
reproduction can reasonably be considered applicable to the registered
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