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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Type of study / information:
The objective of this study was to determine whether the test compound was capable of activating the Androgen Receptor.
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The objective of this study was to determine whether the test compound was capable of activating the Androgen Receptor by using a commercially available U2OS reporter assay.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

Any other information on results incl. tables

Androgen Receptor Translocation Assay Results

Name

AR translocation AC50 (nuclear intensity)

Cytotoxicity AC50

Comment

Test substance

154 µM

33.8 µM

 

Dihydrotestosterone

0.072 nM

NR

Positive control AR

NR = No response

Applicant's summary and conclusion

Conclusions:
The AR translocation AC50 (Nuclear intensity) value for the test substance was 154 µM and the cytotoxicity value was 33.8 µM.