Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-378-9 | CAS number: 5384-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 4,4'-methylenedi-2,6-xylenol
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- 4,4'-methylenedi-2,6-xylenol
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of 4,4'-methylenebis(2,6-dimethylphenol) for effects in the environment:
The chemical 4,4'-methylenebis(2,6-dimethylphenol) (CAS no. 5384-21-4) is used in synthesis of organic chemicals. The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for 4,4'-methylenebis(2,6-dimethylphenol). The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.
Persistence assessment
The tested substance fulfils the P criterion within Annex XIII based on the assessment that here follows:
Biotic degradation
In a prediction done by using the Estimation Programs Interface Suite (2018) was run to predict the biodegradation potential of the test chemical4,4'-methylenebis(2,6-dimethylphenol)(CAS no. 5384-21-4)in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4,4'-methylenebis(2,6-dimethylphenol)is expected to be not readily biodegradable.
Experimental results from the read across substances also indicate that they are not readily biodegradable.
Thus, based on the available information, it indicates that chemical 4,4'-methylenebis(2,6-dimethylphenol) can be expected to be not readily biodegradable in water and thus likely to be persistent (P) in nature.
Environmental fate
According to the fugacity model levels III, the most likely environmental fate for this test chemical is soil (i.e.estimated to 61.8%). In soil,4,4'-methylenebis(2,6-dimethylphenol)was expected to have negligible to slow mobility based upon a Log KOC value of 3.9 to 5.03, respectively. The half-life in soil (75 days estimated by EPI suite) indicates that the chemical is not persistent in soil and the exposure risk to soil dwelling animals is moderate to low.
If released in to the environment, 32.4% of the chemical will partition into sediment according to the Mackay fugacity model level III in EPI suite version 4.1 (2017). However, the half-life (337.5 days estimated by EPI suite) indicates that the substance is persistent in sediment andthe exposure risk to sediment animals is moderate to high.
If released in to the environment, 5.86% of the chemical will partition into water according to the Mackay fugacity model level III in EPI suite version 4.1 (2017). However, the half-life (37.5 days estimated by EPI suite) indicates that the substance is not persistent in water andthe exposure risk to aquatic animals is moderate to low.
Thus, based on the available information, it has been concluded that 4,4'-methylenebis(2,6-dimethylphenol) is considered to be persistent (P) in nature.
Bioaccumulation assessment
The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:
The estimated BCF value from authoritative databases was determined to beranges from 1 to 1765, respectively and the octanol water partition coefficient of the test chemical was estimated to be 3.75, respectively, which is less than the threshold of 4.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.
Toxicity assessment
The tested substance fulfils the T criterion within Annex XIII based on the assessment that here follows:
Mammals
The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1(oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).
Aquatic organisms
All of the available short-term eco-toxicity data for aq. algae for the substance4,4'-methylenebis(2,6-dimethylphenol)indicates the LC50/EC50 value to be > 18.05 mg/L, respectively and on the basis ofthe various experimental studies ofshort term eco-toxicity data for fish and aq. invertebratesof the structurally and functionally similar read across chemical (including the biodegradability of read across chemical) and applying the weight of evidence approach, the LC50/EC50 value was determined to be ranges from > 0.01 to 5 mg/l, respectively. These value suggest that the substance is likely to be hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be classified in ‘Aquatic Acute Category 1’ as per the CLP regulation.
Based on the long-term eco-toxicity data for fish for the substance4,4'-methylenebis(2,6-dimethylphenol)indicates the NOEC value to be 0.036 mg/L and on the basis ofthe various experimental studies oflong term eco-toxicity data for aq. Invertebratesof the structurally and functionally similar read across chemical (including the biodegradability of read across chemical) and applying the weight of evidence approach, the NOEC value was determined to be ranges from > 0.0057 to 0.044 mg/l and EC50 value was determined to be 0.02 mg/l, respectively. These value suggest that the substance is likely to be hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be classified in ‘Aquatic Chronic Category 1’ as per the CLP regulation.
By speculation, long-term NOEC for aquatic organisms were expected for the substance at concentration below 0.01 mg/L based on the data mentioned above.
The chemical was therefore considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.
Conclusion
Based on critical, independent and collective evaluation of information summarized herein, the tested compound fulfils the P and T criterion but does not fulfil the B criterion and has therefore not been classified as a PBT compound within Annex XIII
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.