Registration Dossier
Registration Dossier
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EC number: 226-378-9 | CAS number: 5384-21-4
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is summaries based on the information of the read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE 1 approach was prepared on the basis of two sediment toxicity studies reported as:
WoE 2 and WoE 3 - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Remarks:
- WoE 2: no and WoE 3: no data available
- Test organisms (species):
- Chironomus riparius
- Details on test organisms:
- WoE 2 and WoE 3:
Species Latin Name: Chironomus riparius
Species Common Name: Midge - Study type:
- laboratory study
- Test type:
- static
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Remarks:
- WoE2: DUTCH STD WATER
- Duration:
- 48 h
- Exposure phase:
- total exposure duration
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 800 - < 910 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- The median lethal concentration of test chemical was reported to be in the range of 800 to 910 mg/L, respectively.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the read across chemical and applying the weight of evidence approach, the effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be in the range of 800 to 910 mg/L, respectively.
- Executive summary:
Effect of test chemical was summaried based on the read across chemicals and applying the weight of evidence approach; details are mentioned beow:
The effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be 800 mg/L.
The effect of test chemical on chironomus riparius, was studied for 48 hours duration. based on the mortality the LC50 was reported to be 910 mg/L.
On the basis of the read across chemical and applying the weight of evidence approach, the effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be in the range of 800 to 910 mg/L, respectively.
Reference
Description of key information
On the basis of the read across chemical and applying the weight of evidence approach, the effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be in the range of 800 to 910 mg/L, respectively.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 800 mg/kg sediment dw
Additional information
Effect of test chemical was summaried based on the read across chemicals and applying the weight of evidence approach; details are mentioned beow:
The effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be 800 mg/L.
The effect of test chemical on chironomus riparius, was studied for 48 hours duration. based on the mortality the LC50 was reported to be 910 mg/L.
On the basis of the read across chemical and applying the weight of evidence approach, the effect of test chemical was studied on Chironomus riparius. for the period of 48 hours under static conditions. The medain lethal concentation of test chemical for 48 hours duration was reported to be in the range of 800 to 910 mg/L, respectively.
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