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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of various test chemicals
Justification for type of information:
Data is from handbook or collection of data
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
WoE report is based on the three toxicity study of daphnia magna for the period of 48h.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
Common name water flea
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
0.346 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: other details not known
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
0.075 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: other details not known
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 0.01 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: other details not known
Validity criteria fulfilled:
not specified
Conclusions:
The range of median effective concentration of test chemical to daphnia magna was determined to be >0.010 - 0.346 mg/L
Executive summary:

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on Daphnia magna. The studies are as mentioned below

Firstly, Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 0.346 mg/l for in 48 hrs.

Secondly, both studies from authoritative database outlines the effect of test chemical on the daphnia magna for the period of 48 h. The range median effective concentration of test chemical to daphnia magna is >0.010 - 0.075 mg/L.

The toxicity range for the test chemical was determined to be >0.010 - 0.346 mg/L

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic acute 1 category as per the criteria mentioned in CLP regulation.

Description of key information

The range of median effective concentration of test chemical to daphnia magna was determined to be 0.010 - 0.346 mg/L

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
0.346 mg/L

Additional information

Data available from various sources for test chemical and read across chemicals has been reviewed to determine the toxicity of the test chemical on Daphnia magna. The studies are as mentioned below

Firstly, Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 0.346 mg/l for in 48 hrs.

Secondly, both studies from authoritative database outlines the effect of test chemical on the daphnia magna for the period of 48 h. The range median effective concentration of test chemical to daphnia magna is >0.010 - 0.075 mg/L.

The toxicity range for the test chemical was determined to be >0.010 - 0.346 mg/L

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic acute 1 category as per the criteria mentioned in CLP regulation.