4,4'-methylenedi-2,6-xylenol

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various test chemicals

Justification for type of information:

Experimental data of various test chemicals is from collection of data

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

WoE report is based on the three toxicity study of daphnia magna for 21.0 days.

GLP compliance:

no

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Details on test organisms:

Common name: Daphnia magna

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.044 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: other details not known

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.011 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: other details not known

Duration:

21 d

Dose descriptor:

EC50

Effect conc.:

0.02 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: other details not known

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

> 0.006 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: other details not known

Validity criteria fulfilled:

not specified

Conclusions:

The NOEC value of test chemical on the daphnia magna was determined to be in a range of 0.0057-0.044 mg/L.

Executive summary:

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna, the studies are mentioned below.

Study based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the NOEC value for short term toxicity to aquatic invertebrates was predicted to be 0.044 mg/l for in 21 days.

Another two studies from the authoritative database, The test outlines the effect of the test chemical on the daphnia magna for the period of 21.0 days on their reproduction capacity. Based on the out comes the NOEC of the test chemial to the test species was determined to be in range of 0.0057- 0.011 mg/L.

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 1 category as per the criteria mentioned in CLP regulation.

Description of key information

The NOEC value of test chemical on the daphnia magna was determined to be in a range of 0.0057-0.044 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.044 mg/L

Additional information

Data available from various sources for test chemical and read across chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna, the studies are mentioned below.

Study based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the NOEC value for short term toxicity to aquatic invertebrates was predicted to be 0.044 mg/l for in 21 days.

Another two studies from the authoritative database,The test outlines the effect of the test chemical on the daphnia magna for the period of 21.0 days on their reproduction capacity. Based on the out comes the NOEC of the test chemial to the test species was determined to be in range of 0.0057- 0.011 mg/L.

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 1 category as per the criteria mentioned in CLP regulation.