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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of various test chemicals
Justification for type of information:
Experimental data of various test chemicals is from collection of data
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
WoE report is based on the three toxicity study of daphnia magna for 21.0 days.
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
Common name: Daphnia magna
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.044 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: other details not known
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.011 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: other details not known
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.02 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: other details not known
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
> 0.006 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: other details not known
Validity criteria fulfilled:
not specified
Conclusions:
The NOEC value of test chemical on the daphnia magna was determined to be in a range of 0.0057-0.044 mg/L.
Executive summary:

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna, the studies are mentioned below.

Study based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the NOEC value for short term toxicity to aquatic invertebrates was predicted to be 0.044 mg/l for in 21 days.

Another two studies from the authoritative database, The test outlines the effect of the test chemical on the daphnia magna for the period of 21.0 days on their reproduction capacity. Based on the out comes the NOEC of the test chemial to the test species was determined to be in range of 0.0057- 0.011 mg/L.

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 1 category as per the criteria mentioned in CLP regulation.

Description of key information

The NOEC value of test chemical on the daphnia magna was determined to be in a range of 0.0057-0.044 mg/L.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.044 mg/L

Additional information

Data available from various sources for test chemical and read across chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna, the studies are mentioned below.

Study based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the NOEC value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the NOEC value for short term toxicity to aquatic invertebrates was predicted to be 0.044 mg/l for in 21 days.

Another two studies from the authoritative database,The test outlines the effect of the test chemical on the daphnia magna for the period of 21.0 days on their reproduction capacity. Based on the out comes the NOEC of the test chemial to the test species was determined to be in range of 0.0057- 0.011 mg/L.

Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 1 category as per the criteria mentioned in CLP regulation.