Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation in water:

Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical is expected to be not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 5.86  % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be  37.5   days ( 900  hrs). The half-life ( 37.5  days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is lowwhereas the half-life period of test chemical in sediment is estimated to be  337.5 days ( 8100 hrs). Based on this half-life value, it indicates that test chemical is persistent in sediment.

Biodegradation in Soil:

The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 61.8 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .

Additional information

Biodegradation in water:

Different studies have been reviewed for biodegradation in water endpoint for test chemical and its read across chemicals and their results are summarized below.

 In first study the Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical is expected to be not readily biodegradable.

Next study was experimental study reviewed from authoritative database( J check) in this study the Biodegradation experiment was carried out of test chemical by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by HPLC .The initial concentration of test chemical was 100 mg/L. After 4 weeks of incubation percent biodegradation of test chemical was observed to be 7.0 % by BOD (O2 consumption) parameter, 0.0 by TOC removal parameter and 0.0 % by test material analysis by HPLC in 28 days. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable.

Last was also experimental study reviewed from j check in this study the Biodegradation experiment was performed for test chemical by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by HPLC .The initial concentration of test chemical was 100 mg/L. After 4 weeks of incubation Percent biodegradation of test chemical was observed to be 2.0 % by BOD (O2 consumption) parameter and 1.0 % by test material analysis by HPLC parameter in 28 days. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable.

By considering results of all the studies mentioned above it is concluded that test chemical is not readily biodegradable.

Biodegradation in water and sediments:

Estimation Programs Interface (EPI Suite, 2018) prediction model was run to predict the half-life in water and sediment for the test chemical. If released in to the environment, 5.86  % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be  37.5   days ( 900  hrs). The half-life ( 37.5  days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is lowwhereas the half-life period of test chemical in sediment is estimated to be  337.5 days ( 8100 hrs). Based on this half-life value, it indicates that test chemical is persistent in sediment.

Biodegradation in Soil:

The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2018). If released into the environment, 61.8 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .