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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental results of test chemicals
Justification for type of information:
Data for the target chemical is summarized based on the test chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as- 2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Transformation products:
not specified
Type:
not specified
Remarks on result:
other: 2. test chemical is not hydrolysable
Type:
not specified
Remarks on result:
other: 3. test chemical is not hydrolysable due to lack of functional group
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the results of both the studies and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.
Executive summary:

Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:

In first study it was mentioned that the compounds containing carbon, hydrogen, and oxygen, esters and epoxides are susceptible to hydrolysis under the OECD test conditions (OECD Guideline 111). For these hydrolysis reactions to occur, there must be 1) an electrophylic carbon atom which is 'attacked' by oxygen; and 2) a 'leaving group' which departs from the attacked carbon atom. The hydrolysis reaction of test chemical would occur by attack of water or OH- at C1, because this is the most electropositive carbon in this molecule due to the electron withdrawing effect of the phenolic OH group and the product of this reaction would be test chemical itself, indicating that there would be no net hydrolysis.

Therefore, test chemical would be hydrolytically stable under the conditions of the OECD test (OECD Guideline 111)

another study was reviewed fom authoritative database (HSDB) in this the test chemical is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups which menas it is stable and not hydrolysable.

On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.

Description of key information

On the basis of the results of both the studies and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.

Key value for chemical safety assessment

Additional information

Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:

In first study it was mentioned that the compounds containing carbon, hydrogen, and oxygen, esters and epoxides are susceptible to hydrolysis under the OECD test conditions (OECD Guideline 111). For these hydrolysis reactions to occur, there must be 1) an electrophylic carbon atom which is 'attacked' by oxygen; and 2) a 'leaving group' which departs from the attacked carbon atom. The hydrolysis reaction of test chemical would occur by attack of water or OH- at C1, because this is the most electropositive carbon in this molecule due to the electron withdrawing effect of the phenolic OH group and the product of this reaction would be test chemical itself, indicating that there would be no net hydrolysis.

Therefore, test chemical would be hydrolytically stable under the conditions of the OECD test (OECD Guideline 111)

Another study was reviewed fom authoritative database (HSDB) in this the test chemical is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups which menas it is stable and not hydrolysable.

On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.