Registration Dossier
Registration Dossier
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EC number: 226-378-9 | CAS number: 5384-21-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- WoE 2. and WoE 3.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Transformation products:
- not specified
- Type:
- not specified
- Remarks on result:
- other: 2. test chemical is not hydrolysable
- Type:
- not specified
- Remarks on result:
- other: 3. test chemical is not hydrolysable due to lack of functional group
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the results of both the studies and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.
- Executive summary:
Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:
In first study it was mentioned that the compounds containing carbon, hydrogen, and oxygen, esters and epoxides are susceptible to hydrolysis under the OECD test conditions (OECD Guideline 111). For these hydrolysis reactions to occur, there must be 1) an electrophylic carbon atom which is 'attacked' by oxygen; and 2) a 'leaving group' which departs from the attacked carbon atom. The hydrolysis reaction of test chemical would occur by attack of water or OH- at C1, because this is the most electropositive carbon in this molecule due to the electron withdrawing effect of the phenolic OH group and the product of this reaction would be test chemical itself, indicating that there would be no net hydrolysis.
Therefore, test chemical would be hydrolytically stable under the conditions of the OECD test (OECD Guideline 111)
another study was reviewed fom authoritative database (HSDB) in this the test chemical is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups which menas it is stable and not hydrolysable.
On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.
Reference
Description of key information
On the basis of the results of both the studies and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.
Key value for chemical safety assessment
Additional information
Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:
In first study it was mentioned that the compounds containing carbon, hydrogen, and oxygen, esters and epoxides are susceptible to hydrolysis under the OECD test conditions (OECD Guideline 111). For these hydrolysis reactions to occur, there must be 1) an electrophylic carbon atom which is 'attacked' by oxygen; and 2) a 'leaving group' which departs from the attacked carbon atom. The hydrolysis reaction of test chemical would occur by attack of water or OH- at C1, because this is the most electropositive carbon in this molecule due to the electron withdrawing effect of the phenolic OH group and the product of this reaction would be test chemical itself, indicating that there would be no net hydrolysis.
Therefore, test chemical would be hydrolytically stable under the conditions of the OECD test (OECD Guideline 111)
Another study was reviewed fom authoritative database (HSDB) in this the test chemical is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups which menas it is stable and not hydrolysable.
On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, it can be concluded that the test chemical is not hydrolysable.
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