Registration Dossier
Registration Dossier
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EC number: 200-655-4 | CAS number: 67-48-1
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 112.9 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Derivation of PNECs
The PNECfreshwater, PNECmarine water, PNECintermittent release, PNECsediment-freshwater, PNECsediment-marine-water and PNECsoil are not derived as no effects have been observed up to the limit doses in the aquatic freshwater studies. Therefore, no hazard for freshwater (sediment) organisms is identified. Furthermore, no hazard for marine water (sediment) organisms or soil organisms is expected.
The PNECstp is calculated by application of an assessment factor (1).
The PNECair and PNECsecondary poisoning are not considered as relevant based on the chemical structure and intrinsic properties of the registered substance.
The utilized procedures are described in detail in the ECHA REACH Guidance of May 2008, Chapter R.10 ("Characterisation of dose [concentration]-response for environment").
Environmental classification and labeling
Experimental and reliable QSAR-based results are available for evaluating biodegradation, metabolism and toxicity of Choline chloride towards aquatic vertebrate and invertebrate species. Beside acute toxicity data for three trophic levels (i.e. fish, daphnids and algae), also adequate long-term data are available (i.e. daphnids and algae). Choline chloride was found to be rapidly biodegradable (BASF AG, 1984) and based on the logPow of -3.77 (BASF AG, 1988) and BCF of 3.16 L/kg (Chemservice S.A., 2018b), no bioaccumulation in aquatic organisms is expected. The test substance was found to be not acutely toxic at concentrations upon 500 mg/L or even higher (for details, please refer to the different studies conducted by BASF AG). The most critical NOEC(21d) was found as 30.2 mg/L in an experiment conducted according to OECD 211 with Daphnia magna (MOE Japan, 1999). Based upon these results and in reference to Regulation (EC) No 1272/2008, Choline chloride has not to be classified and labelled with respect to environmental hazards.
Conclusion on classification
In accordance with Regulation (EC) No 1272/2008 (Classification, labelling and packaging of substances and mixtures, amending Regulation (EC) No. 1907/2006), Choline chloride has not to be classified and labelled with respect to environmental hazards.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
