Choline chloride

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The present data are taken from secondary literature (OECD SIDS report), no further details are available and hence, the reliability cannot be assigned.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Type of method:

other: no data

Water solubility:

650 g/L

pH:

6 - 7

Remarks on result:

other: Test temperature unknown; also, since the test item consists of only 50% choline chloride, it is possible that the actual water solubility is only 325 g/L.

Conclusions:

Interpretation of results: very soluble (> 10000 mg/L)
The data was gained from a powder only containing 50% choline chloride. Hence, it is possible, that the actual water solubility of choline chloride is not 650 g/L but only 325 g/L.
Also, data was gained from secondary literature referring to company data without proof. So, the results are not considered as reliable, but will be nevertheless used for the assessment of choline chloride until the data from the new, planned experimental study will be available, because the value is in the expected range taking into account the ionic structure and rather small molecular weight, and the classification as "very soluble" is unlikely to change.

Executive summary:

The water solubility of the test item (choline chloride 50 ± 1%, silicic acid ca. 35 % (colloidal), water ca. 15%) was determined to be 650g/L, hence, choline chloride is classified as very soluble.

Description of key information

Water solubility: 650 g/L (choline chloride 50±1%, silicic acid ca. 35 % (colloidal), water ca. 15%), very soluble

Key value for chemical safety assessment

Water solubility:

650 g/L

Additional information

The data was gained from secondary literature referring to company data without proof (OECD SIDS, 2004). So, the results are not considered as reliable, but will be nevertheless used for the assessment of choline chloride, because the value is in the expected range taking into account the ionic structure and rather small molecular weight, and the classification as "very soluble" is unlikely to be false. This will be furthermore not influenced by the fact that the data was gained from a powder only containing 50% choline chloride, which could bear the possibility, that the actual water solubility of choline chloride is not 650 g/L but only 325 g/L.

However, due to the reliability of the data source (Klimisch 4), the available data is not considered as fully sufficient to meet the tonnage-driven data requirements under REACH, and an additional study will be conducted and submitted via spontaneous dossier update.