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EC number: 200-655-4 | CAS number: 67-48-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23.10.2013 - 21.06.2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- To apply this method, the preparation of a saturated solution of test item in water is required. Since this is not possible for this test item, a homemade method described in the External method EM/00408/01 from Competence Center Analytics, BASF SE (chapt
- Principles of method if other than guideline:
- To apply this method, the preparation of a saturated solution of test item in water is required. Since this is not possible for this test item, a homemade method described in the External method EM/00408/01 from Competence Center Analytics, BASF SE (chapter 4: visual method) was applied to investigate complete miscibility.
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- >= 793 - < 897 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- ca. 0.25 - ca. 50 h
- Temp.:
- 20 °C
- pH:
- 5.9 - 8.1
- Details on results:
- The mixtures 1:9, 1:1 and 8:2 were homogeneous, clear and colorless. The mixture 9:1 was lumpy and no liquid phase could be seen.
After conditioning overnight at 20.0°C ± 0.5°C, no changes were observed.
The water solubility of the test item is ≥ 79.3 g/100g and < 89.7 g/100g (m test item / m mixture) at T = 23°C and at T = 20°C ± 0.5°C. - Conclusions:
- The water solubility of the test item is ≥ 79.3 g/100g and < 89.7 g/100g (m test item / m mixture) at T = 23°C and at T = 20°C ± 0.5°C.
- Executive summary:
The water solubility of substances with an expected high solubility is normally determined according to flask method described in OECD Guideline for the Testing of Chemicals 105. To apply this method, the preparation of a saturated solution of test item in water is required. Since this is not possible for this test item, a homemade method described in the External method EM/00408/01 from Competence Center Analytics, BASF SE (chapter 4: visual method) was applied to investigate complete miscibility.
The water solubility of the test item is ≥ 79.3 g/100g and < 89.7 g/100g (m test item / m mixture) at T = 23°C and at T = 20°C ± 0.5°C.
Reference
Description of key information
The water solubility of substances with an expected high solubility is normally determined according to flask method described in OECD Guideline for the Testing of Chemicals 105. To apply this method, the preparation of a saturated solution of test item in water is required. Since this is not possible for this test item, a homemade method described in the External method EM/00408/01 from Competence Center Analytics, BASF SE (chapter 4: visual method) was applied to investigate complete miscibility.
The water solubility of the test item is ≥ 79.3 g/100 g and < 89.7 g/100 g (m test item / m mixture) at T = 23 °C and at T = 20 °C ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 793 g/L
- at the temperature of:
- 23 °C
Additional information
The water solubility was tested via an experimental study to show complete miscibility. As the test substance is a solid and the solvent of course liquid this is not easy due to the change of aggregate state during testing. Therefore, the solubility is indicated as range and the lower value is used for the chemical safety assessment. As conclusion it was found that the substance is very soluble in water which is supported via evaluation of different sources: Handbook data, calculation and assessment of secondary literature.
The available supporting information is a calculation that led to a solubility of 1000 g/L which is in line with the also available handbook data, which stated that the substance is very soluble in water. The experimental data from the also available secondary literature confirms that fact as here a water solubility of 650 g/L for the test item is stated. All these values are in the expected range taking into account the ionic structure and rather small molecular weight, and the classification as "very soluble" applies.
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