Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-655-4 | CAS number: 67-48-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Calculation with BCFBAF v3.02 (EPIWIN software by US-EPA): 3.16 L/kg wet-wt, bioaccumulation is not expected.
Additional information
The potential for bioaccumulation in aquatic organisms (most likely in fish) was not determined experimentally for Choline chloride. Based on the intrinsic properties of the test substance (i.e. logPow of -3.77, BASF AG, 1988), this study can be waived in accordance to REACH, Annex IX, Section 9.3.2, column 2.
Since the Bioconcentration Factor (BCF) is an important parameter for the chemical safety assessment of the substance, the EPIWIN software BCFBAF v3.02 was used to determine this value for Choline chloride (Chemservice S.A., 2013, updated 2022). Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was predicted. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 0.893 L/kg wet-wt is the result. These results confirm that bioaccumulation in aquatic organisms is unlikely.
Also, terrestrial bioaccumulation of Choline chloride is not expected. However, no information is available, and this endpoint is no mandatory requirement under REACH.
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