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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Study performed on Choline chloride according to OECD Guideline 102 and 103, the latter with minor restrictions: The method used was the differential thermal analysis, and it is not conclusive whether the observed reaction os attributed to boiling or decomposition. Report only available in German, but applicant employes native speaker.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Deviations:
no
GLP compliance:
not specified
Type of method:
differential thermal analysis
Boiling pt.:
ca. 300 °C
Atm. press.:
ca. 1 013 mBar
Decomposition:
ambiguous
Remarks:
second thermal difference was denoted at 300°C
Decomp. temp.:
ca. 300 °C
Remarks on result:
other: First signs of an subsequent reaction were denoted at 250°C, the maximum of this reaction was at 300°C. However, the nature of the test method does not allow to differentiate between boiling and decomposition temperature.

First signs of an exothermal reaction at ca. 110°C

The maximum of this reaction is ca. 200°C

Subsequent reaction starts at ca. 250°C with a maximum at 300°C

Heat released at first reaction: ca. 200 J/g

Heat released at subsequent reaction: ca. 160 J/g

Conclusions:
The study was performed equivalent to OECD guideline 103 using differential thermal analysis (DTA) and was classified as Klimisch 2. Hence, the results can be considered as reliable. However, the nature of the test method does not allow to differentiate between boiling point and decomposition temperature, so cannot be clearly determined whether the subsequent exothermal reaction with a maximum at 300°C (starting at 250°C) is attributed to boiling or decomposing.
Executive summary:

The boiling point / decomposition temperature was determined equivalent to OECD guideline 103 using differential thermal analysis. The maximum of the subsequent reaction was at ca. 300°C, which corresponds either to the boiling point or decomposition temperature.

The study was classified as acceptable and satisfies the requirements of OECD 103.

Description of key information

Boiling point / Decomposition temperature: ca. 300°C at 1013 mbar (OECD 103, differential thermal analysis)
Decomposition temperature: 302–305°C
Decomposition temperature: 305°C
In summary: Boiling point cannot be determined because the substance decomposes before boiling, decomposition temperature: ca. 300°C

Key value for chemical safety assessment

Additional information

The Key study (BASF, 1983) was performed equivalent to OECD Guideline 103 using differential thermal analysis (DTA) and was classified as Klimisch 2. Hence, the results can be considered as reliable. However, the nature of the test method does not allow to differentiate between boiling point and decomposition temperature, so cannot be clearly determined whether the subsequent exothermal reaction with a maximum at 300°C (starting at 250°C) is attributed to boiling or decomposing. Hence, two additional supporting values were taken from peer-reviewed databases. Here, it is stated clearly that the compound decomposes at 302-305°C (GESTIS, 2013) resp. 305°C (HSDB 2013 / Lide DR, 1994), which allow to draw the conclusion that the examined exothermal reaction was attributed to decomposition rather than boiling.

All three studies were classified as Klimisch 2, and the results can be generally considered to be reliable. Furthermore, all values are in the same small range (300°C – 305°C), which can be easily explained by the possible presence of minor impurities, differences due to different determination methods or generally by a certain margin of error accompanying all experimental determinations.

Hence, the results are consistent and only the decomposition temperature could be determined and denoted in IUCLID, but not the boiling point. This in in congruence with REACH Annex VII section 7.3 Column 2 stating that the boiling point does not need to be determined if the substance decomposes before boiling. So, no datagaps were determined, no further testing is required and the decomposition temperature of ca. 300°C can be used for risk assessment.