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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The present data are taken from secondary literature (OECD SIDS report), no further details are available and hence, the reliability cannot be assigned. Nevertheless the derivation is schientifically acceptable and comprehensible.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline required
Principles of method if other than guideline:
scientifically acceptable derivation
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
Remarks on result:
other: The substance dissociates readily

Choline chloride is a quaternary amine salt, it dissociates in water into the corresponding positively charged quaternary hydroxyl alkylammonium ion and the negatively charged chloride ion.

Conclusions:
Choline chloride is a quaternary amine salt, it can be easily concluded that it dissociates in water into the corresponding positively charged quaternary hydroxyl alkylammonium ion and the negatively charged chloride ion.
The data was gained from secondary literature. So, in general the results would not be considered as reliable, but will be nevertheless used for the assessment of choline chloride until the data from the new, planned experimental study will be available, because the conclusion and derivation meets scientific principles taking into account the ionic structure.
Executive summary:

Choline chloride is a quaternary amine salt, it can be easily concluded that it dissociates in water into the corresponding positively charged quaternary hydroxyl alkylammonium ion and the negatively charged chloride ion.

Description of key information

Choline chloride is a quaternary amine salt, it dissociates in water into the corresponding positively charged quaternary hydroxyl alkylammonium ion and the negatively charged chloride ion.

Key value for chemical safety assessment

Additional information

Choline chloride is a quaternary amine salt, it can be easily concluded that it dissociates in water into the corresponding positively charged quaternary hydroxyl alkylammonium ion and the negatively charged chloride ion.

The data was gained from secondary literature (OECD SIDS, 2004). So, in general the results would not be considered as reliable, but will be nevertheless used for the assessment of choline chloride until the data from the new, planned experimental study will be available, because the conclusion and derivation meets scientific principles taking into account the ionic structure.

However, due to the reliability of the data source (Klimisch 4), the available data is not considered as fully sufficient to meet the tonnage-driven data requirements under REACH, and an additional study will be conducted and submitted via spontaneous dossier update.

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