Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

skin irritation / corrosion, other
other: Human evidence is referenced.
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is peer reviewed and is referenced on the Toxnet website (
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
review article or handbook

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
No information is presented on the guideline followed or method employed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloropropionic acid
EC Number:
EC Name:
2-chloropropionic acid
Cas Number:
Molecular formula:
2-chloropropanoic acid
Details on test material:
The substance in the cited reference is 2-Chloropropionic acid, the racemate of L-2-Chloropropionic acid. The physical properties of optical enantiomers are not distinguishable and with regard to physical properties they are considered equivalent. As the corrosivity of a substance is largely related to the pH, it was considered that the data for the racemate was applicable to support the case for the single isomer.
No details on the purity or source of the 2-chloropropionic acid are given in the reference.

Test animals

other: No data
not specified
Details on test animals or test system and environmental conditions:
No addtional data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
not specified
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Remarks on result:
positive indication of irritation

Any other information on results incl. tables

The internet source of this peer reviewed result does not give any additional data on time period or scores although an additional comment made indicates that the substance possesses some potential for absorption through the skin in acutely toxic amounts. No additional information is given.

Applicant's summary and conclusion

Interpretation of results:
other: Corrosive
Criteria used for interpretation of results: EU
Available human data indicates corrosivity.
Executive summary:

No information on the guideline followed or the method employed is given in this source.

The information presented from this source constitutes an assessment of available human and animal data.

Chloropropionic acid is corrosive to skin and eyes and possesses some potential for absorption through the skin in acutely toxic amounts.