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EC number: 411-150-5
CAS number: 29617-66-1
L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
Hind limb weakness and abnormal gait were observed within 2 to 4 weeks.
Weights of liver, spleen, kidneys, heart, testes plus epididymides and
brain were significantly less that in the control group. The organ:body
weight ratios were significantly larger than the corresponding control
ratios for adrenals and lungs. Sodium 2-chloropropionate inhibited
growth of testes as evidenced by the fact that the ratio of the weight
of testes plus epididymides to the body weight was significantly smaller
than in the control group. Degeneration of germ cells was also observed.
A feeding study was conducted in six male rats by mixing the substance
with pulverised feed at 0.04 moles substance/kg feed which was fedad
libitumfor 12 weeks. Received doses declined from approx 430
mg/kg/day at the start of the study to 270 mg/kg/day at the end. Hind
limb weakness and abnormal gait were observed within 2-4 weeks. Weights
of liver, spleen, kidneys, heart, testes plus epididymides and brain
were significantly less than in the control group. Prostate weights were
approx 65% of control value, although the difference was not
statistically significant. When organs:bodyweights were considered, only
the testes plus epididymides weight was depressed compared to the
control with increases for adrenals and lungs, although these organs are
not notably sensitive to bodyweight change. It was reported that
2-chloropropionate-treated rats had significantly lower plasma
triglycerides than controls, although this probably reflects the
depressed bodyweight rather than a specific effect. Histologically the
reduced testicular weight accompanied by arrested maturation and
degeneration of germ cells, possibly reflected the substantially reduced
It is evident that the single dose tested was well in excess of the
maximum tolerated dose so that any conclusions drawn must be tentative.
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