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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation, other
Remarks:
other: Human data referenced
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The source is peer reviewed.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No additional information is given on the guideline followed or the method employed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloropropionic acid
EC Number:
209-952-3
EC Name:
2-chloropropionic acid
Cas Number:
598-78-7
Molecular formula:
C3H5ClO2
IUPAC Name:
2-chloropropanoic acid
Details on test material:
The substance in the cited reference is 2-Chloropropionic acid, the racemate of L-2-Chloropropionic acid. The physical properties of optical enantiomers are not distinguishable and with regard to physical properties they are considered equivalent. The corrosivity of a substance is often related to the pH, which is also independant of chirality.
No details on the purity or source of the 2-chloropropionic acid are given in the reference.

Test animals / tissue source

Species:
other: Human observations
Strain:
other: Not applicable
Details on test animals or tissues and environmental conditions:
Not applicable

Test system

Vehicle:
not specified
Controls:
other: No additional data presented
Amount / concentration applied:
No additional data presented
Duration of treatment / exposure:
No additional data presented
Observation period (in vivo):
No additional data presented
Number of animals or in vitro replicates:
Not applicable
Details on study design:
No additional data presented

Results and discussion

In vivo

Results
Basis:
other: Human observation
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
No additional data presented
Other effects:
No additional data presented

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
other: Corrosive
Remarks:
Criteria used for interpretation of results: not specified
Conclusions:
This reference states that "toxicity studies indicate that the substance to be corrosive to eye and skin".
Executive summary:

No information on the guideline followed or the method employed is given in this source.

The information presented from this source constitutes an assessment of available human and animal data.

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