Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 411-150-5 | CAS number: 29617-66-1 L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August - October 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (S)-2-chloropropionic acid
- EC Number:
- 411-150-5
- EC Name:
- (S)-2-chloropropionic acid
- Cas Number:
- 29617-66-1
- Molecular formula:
- Hill formula: C3H5ClO2 CAS formula: C3H5ClO2
- IUPAC Name:
- (2S)-2-chloropropanoic acid
- Details on test material:
- - Name of test material (as cited in study report): L-2-Chloropropionic acid
- Physical state: Liquid
- Analytical purity: 90.4% w/w
- Purity test date: 30th April 1992
- Lot/batch No.: Bx 0071, ADH05138
- Expiration date of the lot/batch: Not specified
- Storage condition of test material: Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Not specified
MAXIMUM DOSE VOLUME APPLIED:
- Amount of vehicle (if gavage): 10ml/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Based on a preliminary study. - Doses:
- Initial dose level of 1000 mg/kg (males /females)
Additional dose levels of 200 and 1500 mg/kg (both sexes) and 500 mg/kg (females only). - No. of animals per sex per dose:
- Five male and five female unless otherwise specified.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Observed for signs of systemic toxicity within 2.5 hours of dosing and again between 4 and 7 hours after dosing. Subsequent observations were made once daily or twice daily where significant signs of toxicity were observed.
- Necropsy of survivors performed: yes on day 15
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 118 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 938 - ca. 1 333
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 575 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 307 - 938
Any other information on results incl. tables
There were no signs of toxicity and no animals died after a dose of 200mg/kg L-2-Chloropropionic acid.
Female rats only were exposed to a dose of 500mg/kg of the test substance. Of the five rats exposed, one showed signs of extreme toxicity (e.g. decreased activity, dehydration, hypothermia, piloerection, reduced foot withdrawal reflex) and was killedin extremison day 2. Two animals showed signs of slight general toxicity (e.g. decreased activity, piloerection, pinched-in sides) and were found dead on day 4. The two animals that survived to the end of the study showed signs of slight general toxicity for up to 9 days and both animals showed reduced stability from day 2 or 3 until the end of the study.
Following doses of 1000 mg/kg to both male and female rats, one male and two females showed signs of extreme toxicity and were killedin extremison day 1 or 3. One female showed signs of slight to moderate toxicity but was found dead on day 3. Surviving animals showed signs of slight to moderate toxicity similar to those seen at lower dose levels but of higher incidence. Reduced stability persisted until the end of the study in all surviving animals.
After dosing with 1500mg/kg, all the males and one female showed signs of slight to moderate toxicity but were never the less found dead on day 2. The remaining females showed signs of extreme toxicity and were killedin extremison days 2 or 3.
Post mortem findings suggested a local irritant effect on the gastrointestinal tract and a possible effect on the liver, particularly in the animals dosed at 1500 mg/kg. An incidence of blood stained urine at this dose level may also have been treatment related.
Table 1 shows a summary of the cumulative mortality data.
Table 1.
Dose Level (mg/kg) |
Day Number |
Number of Deaths |
|
Male |
Female |
||
200 |
- |
0/5 |
0/5 |
15 (total) |
0/5 |
0/5 |
|
500 |
2 |
N/A |
1/5 |
4 |
- |
2/5 |
|
15 (total) |
- |
3/5 |
|
1000 |
1 |
1/5 |
1/5 |
3 |
0/5 |
2/5 |
|
15 (total) |
1/5 |
3/5 |
|
1500 |
2 |
5/5 |
4/5 |
3 |
- |
1/5 |
|
15 (total) |
5/5 |
5/5 |
Applicant's summary and conclusion
- Conclusions:
- The acute oral median lethal dose of L-2-Chloropropionic acid was calculated to be 1118 mg/kg to male rats and 575 mg/kg to female rats.
- Executive summary:
The acute oral toxicity of L-2-Chloropropionic acid was assessed in a guideline study on Wistar albino rats.
Groups of five male and /or five female rats received a single oral dose of 200, 500, 1000 or 1500 mg/kg of the test substance. The animals were assessed daily for signs of toxicity and their bodyweights recorded at various time points throughout the study. All animals were subjected to a macroscopic post mortem examination.
There were no signs of toxicity and no animals died after a dose of 200mg/kg L-2-Chloropropionic acid.
Female rats only were exposed to a dose of 500mg/kg of the test substance.
Three animals were found dead or were killedin extremisby day 4. The two animals that survived to the end of the study showed signs of slight general toxicity up to day 9 and reduced stability until the end of the study.
Following doses of 1000 mg/kg to both male and female rats, one male and three female animals were found dead or were killed in extremis on day 1 or 3. Surviving animals showed signs of slight to moderate toxicity similar to those seen at lower dose levels but with higher incidence. Reduced stability persisted until the end of the study in all surviving animals.
After dosing with 1500mg/kg, all the males and one female showed signs of slight to moderate toxicity but were found dead on day 2. The remaining females showed signs of extreme toxicity and were killedin extremison days 2 or 3.
Post mortem findings suggested a local irritant effect on the gastrointestinal tract and a possible effect on the liver, particularly in the animals dosed at 1500 mg/kg. An incidence of blood stained urine at this dose level may also have been treatment related.
The acute oral median lethal dose of L-2-Chloropropionic acid was calculated to be 1118 mg/kg to male rats and 575 mg/kg to female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.