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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

L-2-Chloropropionic acid is classified under the CLP Regulation EC 1272/2008 Annex VI as Harmful if swallowed, R22 or Acute Toxicity 4 (H302) and Harmful in contact with skin, R21 or Acute Toxicity 4 (H312). A guideline study is reported which supports the Harmful if swallowed, R22 classification.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
575 mg/kg bw

Additional information

L-2-Chloropropionic acid is classified under the CLP Regulation EC 1272/2008 Annex VI as Acute Toxicity 4 (H302: Harmful if swallowed) and Skin Corr. 1A (H314: causes severe skin burns and eye damage).

Annex VII of Regulation (EC) No 1907/2006, section 8.5 states that a study for oral toxicity does not need to be conducted if the substance is classified as corrosive to the skin; however an existing study is available and has been reported.

The study (CTL/P/3892) reports an acute LD50 on female rats of 575 mg/kg/bw and 1118 mg/kg/bw for male rats. These values support the classification listed in Regulation (EC) 1272/2008.

Justification for classification or non-classification

The acute oral toxicity value of 575mg/kg/bw for female rats reported here, supports the Regulation EC 1272/2008 Annex VI classifiaction of Acute Toxicity 4 (H302: Harmful if swallowed).

 

No acute dermal study is available. However based on data available for skin irritation/corrosivity the registrant accepts the official EC 1272/2008 Annex VI classification of Harmful in contact with skin, R21/ Acute Toxicity 4 (H312).