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Description of key information

Key value for chemical safety assessment

Additional information

Calcium chloride is not genotoxic in vivo. Calcium and chloride are both essential nutrients for humans and a daily intake of more than 1000 mg for each of the ions is recommended. As for healthy humans, the tolerable upper intake level for calcium is set at 2500 mg per day (equivalent to 6.9 g CaCl2per day) [1]. For chloride, the reference nutrient intake is set at 2500 mg/day (equivalent to 3.9 g CaCl2per day) [2]. The estimated intake of calcium chloride in a form of food additives (160-345 mg/day) is considerably smaller than these values. Consistent with this, the establishment of an ADI for calcium chloride has not been deemed necessary by JECFA [3]. Based on this information, it is concluded that the substance is not carcinogenic and the performance of a carcinogenicity study for calcium chloride is not indicated.

Justification for classification or non-classification