Registration Dossier
Registration Dossier
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EC number: 233-140-8 | CAS number: 10043-52-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of carcinogenic effect of bracken fern (Pteridium aquilinum) by various chemicals
- Author:
- Pamukcu, A.M., Yalciner, S. and Bryan, G.T.
- Year:
- 1 977
- Bibliographic source:
- Cancer, 40, 2450-2454
Materials and methods
- Principles of method if other than guideline:
- Rats received diet enriched with 20 mg CaCl2 per gram diet for a period of 1 year. Examinations included body weight and histopathological examination of the gastro-intestinal tract, urinary tract, liver, heart, brain and spleen.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Calcium chloride
- EC Number:
- 233-140-8
- EC Name:
- Calcium chloride
- Cas Number:
- 10043-52-4
- Molecular formula:
- CaCl2
- IUPAC Name:
- calcium dichloride
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 12 months
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20000 ppm
Basis:
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- >= 20 000 ppm
- Sex:
- not specified
- Remarks on result:
- other: no neoplastic lesions observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
