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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Inhibition of carcinogenic effect of bracken fern (Pteridium aquilinum) by various chemicals
Author:
Pamukcu, A.M., Yalciner, S. and Bryan, G.T.
Year:
1977
Bibliographic source:
Cancer, 40, 2450-2454

Materials and methods

Principles of method if other than guideline:
Rats received diet enriched with 20 mg CaCl2 per gram diet for a period of 1 year. Examinations included body weight and histopathological examination of the gastro-intestinal tract, urinary tract, liver, heart, brain and spleen.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
12 months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
20000 ppm
Basis:

Control animals:
yes

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
>= 20 000 ppm
Sex:
not specified
Remarks on result:
other: no neoplastic lesions observed

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion