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EC number: 233-140-8 | CAS number: 10043-52-4
The dermal LD50 was >5000 mg/kg. All four rabbits topically
treated with the test material survived. No adverse effects
were observed following treatment. Topical responses observed
on the application sites of test rabbits 24 hours post-treatment
included slight (1/4) or moderate (3/4) redness, moderate (3/4)
or marked (1/4) swelling and moderate (2/4) or marked (2/4) necrosis.
Gross necropsy examination of rabbits 2 weeks post-treatment revealed
skin lesions at or near the site of administration, characterized
by scab formation, skin thickening and subchronic inflammation.
Internal observations were not considered to be the result of compound
exposure and/or absorption.
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