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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report that meets generally accepted scientific principles.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Vehicle:
water
Duration of exposure:
24 hours
Doses:
5000 mg/kg
No. of animals per sex per dose:
2

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
no mortality
Clinical signs:
no adverse effects

Any other information on results incl. tables

The dermal LD50 was >5000 mg/kg.  All four rabbits topically 
treated with  the test material survived.  No adverse effects 
were observed following  treatment.  Topical responses observed 
on the application sites of test  rabbits 24 hours post-treatment 
included slight (1/4) or moderate (3/4)  redness, moderate (3/4) 
or marked (1/4) swelling and moderate (2/4) or marked (2/4) necrosis. 
Gross necropsy examination of rabbits 2 weeks post-treatment revealed 
skin lesions at or near the site of administration, characterized 
by scab formation, skin thickening and subchronic inflammation. 
Internal observations were not considered to be the result of compound 
exposure  and/or absorption.

Applicant's summary and conclusion