Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Calcium chloride was negative in the bacterial mutation tests and the mammalian chromosome aberration test, showing no genotoxic potential for calcium chloride.

In addition, calcium chloride is already present in the tissue culture media of the in vitro test systems for genetic toxicity testing, and needed for normal function of the cells in culture. Testing calcium chloride in vitro will affect the cellular homeostasis due to osmolarity and/or pH of the culture medium which might give rise to non-specific effects. Considering these aspects and taken into account that calcium chloride is a normal constituent of the body, no further genotoxicity testing is considered necessary.

Short description of key information:
Based on the results of two bacterial mutation assays and an in vitro chromosome aberration test in Chinese hamster lung fibroblasts, calcium chloride is considered not to have a genotoxic potential.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the negative results of the available in vitro tests, classification of calcium chloride is not warranted in accordance with Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.