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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD Guideline study according to GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test substance: Anhydrous calcium chloride (CaCl2), a white powder,
prepared from calcium chloride dihydrate flakes (Batch No.
Couillet 8/OCT/1985 FLAKES). The test material was solid
at the application time. Upon analysis sample contained:
97.0% CaCl2, 2.2% NaCl and 0.11% Ca(OH)2.

Test animals

Species:
rabbit

Test system

Type of coverage:
occlusive
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
4 hour(s)
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Score:
0
Remarks on result:
other: no effects seen
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0

Any other information on results incl. tables

- Table 1: Scores of the skin reaction of the rabbit after
application of anhydrous calcium chloride at different times after patch removal.
-----------------------------------------------------
Animal Symptom score after
No. ----------------------------------------------
30-60 24 48 72
minutes hours hours hours
-----------------------------------------------------
1 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------
2 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------
3 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Classification: not irritating