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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report that meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Pharmacological studies on Ca meso-tartrate I. Acute and subacute toxicity tests
Author:
Akatsuka, K., Hashimoto, T. and Takeuchi, K.
Year:
1977
Bibliographic source:
Ouyou-Yakuri, 14, 963-975. (in Japanese)

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium chloride
EC Number:
233-140-8
EC Name:
Calcium chloride
Cas Number:
10043-52-4
Molecular formula:
CaCl2
IUPAC Name:
calcium dichloride

Test animals

Species:
mouse
Strain:
ICR
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 5 % Arabic gum in water
No. of animals per sex per dose:
15

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
402 mg/kg bw

Applicant's summary and conclusion