Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
SIDS Initial Assessment Report for calcium chloride
Year:
2002
Bibliographic source:
Chemicals Evaluation and Research Institute (CERI)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Anhydrous calcium chloride (CaCl2), a white powder, prepared from
calcium chloride dihydrate flakes (Batch No.Solvay Couillet 8/OCT/1985
FLAKES). The test material was solid at the application time. Upon
analysis sample contained: 97.0% CaCl2, 2.2% NaCl and 0.11% Ca(OH)2.

Test animals / tissue source

Species:
rabbit

Test system

Details on study design:
not rinsed

Results and discussion

In vivo

Results
Irritation parameter:
other: Severe irritation
Score:
0
Remarks on result:
positive indication of irritation

Applicant's summary and conclusion