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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Taken from OECD SIDS (Guideline study).
Principles of method if other than guideline:
Method: other: EPA/600/4-90/027, EPA/600/6-91/003
GLP compliance:
not specified
Analytical monitoring:
yes
Vehicle:
not specified
Test organisms (species):
Pimephales promelas
Details on test organisms:
a) Size: Not described
b) Age: 1-7 days old
c) Pretreatment: no data
d) Supplier/Source: ENSR, Fort Collins, CO, USA
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4 630 mg/L
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 6 560 mg/L
Basis for effect:
mortality
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
> 6 660 mg/L
Basis for effect:
mortality
Table: Mean LC50 values
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Exposure period 24h 48h 96h
Number of test 3 3 3
LC50 (mg/l)* >6660 >6560 4630
Range (mg/l)** 4700->10000 4390->10000 3930-5360
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* Values are arithmetic mean of 3 tests.
** Range of three LC50s

Description of key information

Eight studies on acute toxicity to fish have been reported, of which 4 were considered reliable with restrictions (K2). These are presented in the current summary. Four other studies were scored K3 and are not further discussed.

The key study (Mount et al. 1997, performed under EPA guideline) estimated the lowest 96-hour LC50 value of 4630 mg/L as result of exposing fathead minnow (Pimephales promelas). The other 3 K2 studies exposing bluegill sunfish (Lepomis macrochirus) (Cairns and Scheier (1959) and Trama (1954)) and mosquitofish (Gambusia affinis) (Wallen et al. 1957) resulted in 96-hour LC50 values between 9500 and 13400 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
4 630 mg/L

Additional information